FAAH inhibitor 1 (Synonyms: Benzothiazole analog 3)

Name: FAAH inhibitor 1
Brand: MedChemExpress
SKU: HY-10862
Rating: 4.5 (0 reviews)

Cat. No.: HY-10862 Pureza: 98.30%: Ficha de datos
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FAAH inhibitor 1 (compound 3) is a selective reversible FAAH inhibitor. FAAH inhibitor 1 has no off-target activity with respect to other serine hydrolases. FAAH inhibitor 1 is exclusively specific against FAAH in rat brain with an IC₅₀ value of 18 nM and had no missing protein bands in all the other tissues. FAAH inhibitor 1 can be used for neurological disorders research.

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FAAH inhibitor 1 Estructura química

No. CAS : 326866-17-5

Tamaño	Stock	Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
200 mg	Obtener un presupuesto
500 mg	Obtener un presupuesto

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Based on 1 Customer Validation

Other Forms of FAAH inhibitor 1:

FAAH inhibitor 1 (Standard) Obtener un presupuesto

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Descripciòn

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	11 nM Compound: 3	Inhibition of human recombinant FAAH expressed in HEK293 cells by [3H]anandamide carbon filtration assay Inhibition of human recombinant FAAH expressed in HEK293 cells by [3H]anandamide carbon filtration assay	[PMID: 19072118]
HEK293	IC₅₀	19 nM Compound: 3	Inhibition of human recombinant FAAH expressed in HEK293 cells preincubated for 60 mins before substrate addition by [3H]anandamide carbon filtration assay Inhibition of human recombinant FAAH expressed in HEK293 cells preincubated for 60 mins before substrate addition by [3H]anandamide carbon filtration assay	[PMID: 19072118]
HEK293	IC₅₀	20 nM Compound: 3	Inhibition of human recombinant FAAH expressed in HEK293 cells preincubated for 5 mins before substrate addition by [3H]anandamide carbon filtration assay Inhibition of human recombinant FAAH expressed in HEK293 cells preincubated for 5 mins before substrate addition by [3H]anandamide carbon filtration assay	[PMID: 19072118]
HEK293	IC₅₀	34 nM Compound: 3	Inhibition of human recombinant FAAH expressed in HEK293 cells preincubated for 30 mins before substrate addition by [3H]anandamide carbon filtration assay Inhibition of human recombinant FAAH expressed in HEK293 cells preincubated for 30 mins before substrate addition by [3H]anandamide carbon filtration assay	[PMID: 19072118]

In Vitro

FAAH inhibitor 1 (compound 3) is a selective reversible FAAH inhibitor with IC₅₀ values of 11, 20, 34 and 19 nM at 0, 5, 30 and 60 min, respectively.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

497.65

Fòrmula

C₂₄H₂₃N₃O₃S₃

No. CAS

326866-17-5

Appearance

Solid

Color

Light yellow to yellow

SMILES

CC1=CC=C(N=C(C2=CC=C(NC(C3CCN(S(=O)(C4=CC=CS4)=O)CC3)=O)C=C2)S5)C5=C1

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvente y solubilidad

In Vitro:

DMSO : 62.5 mg/mL (125.59 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0094 mL	10.0472 mL	20.0944 mL
5 mM	0.4019 mL	2.0094 mL	4.0189 mL
10 mM	0.2009 mL	1.0047 mL	2.0094 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Pureza y Documentación

Purity: 98.30%

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Ficha de datos (270 KB) SDS (393 KB)

COA (245 KB) HNMR (256 KB) LCMS (97 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Wang, Xueqing; Sarris, Katerina; Kage, Karen; et al. Synthesis and Evaluation of Benzothiazole-Based Analogues as Novel, Potent, and Selective Fatty Acid Amide Hydrolase Inhibitors. Journal of Medicinal Chemistry (2009), 52(1), 170-180. [Content Brief]

[2]. Meyers, Marvin J.; Long, Scott A.; Pelc, Matthew J.; et al. Discovery of novel spirocyclic inhibitors of fatty acid amide hydrolase (FAAH). Part 1: Identification of 7-azaspiro[3.5]nonane and 1-oxa-8-azaspiro[4.5]decane as lead scaffolds. Bioorganic & Medicinal Chemistry Letters (2011), 21(21), 6538-6544. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.0094 mL	10.0472 mL	20.0944 mL	50.2361 mL
	5 mM	0.4019 mL	2.0094 mL	4.0189 mL	10.0472 mL
	10 mM	0.2009 mL	1.0047 mL	2.0094 mL	5.0236 mL
	15 mM	0.1340 mL	0.6698 mL	1.3396 mL	3.3491 mL
	20 mM	0.1005 mL	0.5024 mL	1.0047 mL	2.5118 mL
	25 mM	0.0804 mL	0.4019 mL	0.8038 mL	2.0094 mL
	30 mM	0.0670 mL	0.3349 mL	0.6698 mL	1.6745 mL
	40 mM	0.0502 mL	0.2512 mL	0.5024 mL	1.2559 mL
	50 mM	0.0402 mL	0.2009 mL	0.4019 mL	1.0047 mL
	60 mM	0.0335 mL	0.1675 mL	0.3349 mL	0.8373 mL
	80 mM	0.0251 mL	0.1256 mL	0.2512 mL	0.6280 mL
	100 mM	0.0201 mL	0.1005 mL	0.2009 mL	0.5024 mL

FAAH inhibitor 1 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

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FAAH inhibitor 1 (Synonyms: Benzothiazole analog 3)

Revisión del cliente

Other Forms of FAAH inhibitor 1:

FAAH inhibitor 1 Related Antibodies

Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Actividad biológica

Pureza y Documentación

Referencias

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FAAH inhibitor 1 Related Antibodies

Calculadora de molaridad

Calculadora de dilución

Complete Stock Solution Preparation Table

FAAH inhibitor 1 Related Classifications

Keywords:

Productos vistos recientemente:

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