2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. FSHR agonist 1

FSHR agonist 1 is a high affinity and allosteric follicle stimulating hormone receptor (FSHR) agonist with a pEC50 of 7.72. FSHR agonist 1 formes extensive interactions with the TMD to directly activate FSHR.

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FSHR agonist 1

FSHR agonist 1 構造式

CAS 番号 : 1256776-89-2

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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10 mM * 1 mL in DMSO USD 720 在庫あり
Solid
1 mg $280 在庫あり
5 mg $700 在庫あり
10 mg $1120 在庫あり
25 mg $2100 在庫あり
50 mg $3150 在庫あり
100 mg $4750 在庫あり
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FSHR agonist 1 関連抗体

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製品説明

FSHR agonist 1 is a high affinity and allosteric follicle stimulating hormone receptor (FSHR) agonist with a pEC50 of 7.72. FSHR agonist 1 formes extensive interactions with the TMD to directly activate FSHR[1].

IC50 & Target

pEC50: 7.72 (FSHR)[1]
体外実験

The binding of FSHR agonist 1 (compound 21f) to the FSHR TMD pocket induces inward movements of TM6 and TM7, which directly results in FSHR activation[1].
FSHR agonist 1 (compound 21f) can activate FSHR, LHCGR and TSHR with highly potency and efficacy, while the activation potency for FSHR is more than 10-fold higher than LHCGR (pEC50 of 6.26) and TSHR (pEC50 of 6.48)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FSHR agonist 1 関連抗体
分子量

467.62

分子式

C26H33N3O3S
CAS 番号
Appearance

Solid

Color

White to light yellow

SMILES

O=C(N(C(C)(C)C)CC)C1=NC(C2=CC=CS2)=C3C4=C(CCN13)C=C(OC)C(OC(C)C)=C4
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 50 mg/mL (106.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1385 mL 10.6924 mL 21.3849 mL
5 mM 0.4277 mL 2.1385 mL 4.2770 mL
10 mM 0.2138 mL 1.0692 mL 2.1385 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

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C1

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純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1385 mL 10.6924 mL 21.3849 mL 53.4622 mL
5 mM 0.4277 mL 2.1385 mL 4.2770 mL 10.6924 mL
10 mM 0.2138 mL 1.0692 mL 2.1385 mL 5.3462 mL
15 mM 0.1426 mL 0.7128 mL 1.4257 mL 3.5641 mL
20 mM 0.1069 mL 0.5346 mL 1.0692 mL 2.6731 mL
25 mM 0.0855 mL 0.4277 mL 0.8554 mL 2.1385 mL
30 mM 0.0713 mL 0.3564 mL 0.7128 mL 1.7821 mL
40 mM 0.0535 mL 0.2673 mL 0.5346 mL 1.3366 mL
50 mM 0.0428 mL 0.2138 mL 0.4277 mL 1.0692 mL
60 mM 0.0356 mL 0.1782 mL 0.3564 mL 0.8910 mL
80 mM 0.0267 mL 0.1337 mL 0.2673 mL 0.6683 mL
100 mM 0.0214 mL 0.1069 mL 0.2138 mL 0.5346 mL
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FSHR agonist 1 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FSHR agonist 11256776-89-2FSHR agonist1FSHR agonist-1Estrogen Receptor/ERRallostericFSHRTMDLHCGRTSHRInhibitorinhibitorinhibit

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製品名:
FSHR agonist 1
製品番号:
HY-150210
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