2. Metabolic Enzyme/Protease
  3. Phospholipase
  4. GK470

GK470 (compound 28) is an inhibitor of group IVA cytosolic phospholipase A2 (GIVA cPLA2) with an IC50 of 300 nM in vesicle assays. GK470 has anti-inflammatory activity, inhibiting the release of arachidonic acid in SW982 fibroblast-like synoviocytes with an IC50 value of 0.6 μM. GK470 exhibits comparable anti-inflammatory effects to Methotrexate (HY-14519) in a preventive collagen-induced arthritis model and significantly reduces plasma PGE2 levels.

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GK470

GK470 화학구조

CAS No. : 1621517-53-0

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제품 설명

GK470 (compound 28) is an inhibitor of group IVA cytosolic phospholipase A2 (GIVA cPLA2) with an IC50 of 300 nM in vesicle assays. GK470 has anti-inflammatory activity, inhibiting the release of arachidonic acid in SW982 fibroblast-like synoviocytes with an IC50 value of 0.6 μM. GK470 exhibits comparable anti-inflammatory effects to Methotrexate (HY-14519) in a preventive collagen-induced arthritis model and significantly reduces plasma PGE2 levels[1].

분자량

389.51

화학식

C21H27NO4S
CAS No.
SMILES

O=C(OC)C1=CSC(C(COC2=CC=C(C=C2)CCCCCCCC)=O)=N1
선적

Room temperature in continental US; may vary elsewhere.
보관

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Keywords:

GK4701621517-53-0GK 470GK-470PhospholipaseInhibitorsvesicle assaysanti-inflammatoryarachidonic acidSW982 fibroblast-like synoviocytesInhibitorinhibitorinhibit

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상품명:
GK470
Cat. No.:
HY-120050
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