1621517-53-0
Chemical Structure
GK470
- CAS. Nr.: 1621517-53-0
- Formula:C21H27NO4S
- Molecular Weight:389.51
IUPAC Name: methyl 2-(2-(4-octylphenoxy)acetyl)thiazole-4-carboxylate
InChIKey: OUBSYDDAZYCDGZ-UHFFFAOYSA-N
SMILES: O=C(OC)C1=CSC(C(COC2=CC=C(C=C2)CCCCCCCC)=O)=N1
Biological Activity: GK470 (compound 28) is an inhibitor of group IVA cytosolic phospholipase A2 (GIVA cPLA2) with an IC50 of 300 nM in vesicle assays. GK470 has anti-inflammatory activity, inhibiting the release of arachidonic acid in SW982 fibroblast-like synoviocytes with an IC50 value of 0.6 μM. GK470 exhibits comparable anti-inflammatory effects to Methotrexate (HY-14519) in a preventive collagen-induced arthritis model and significantly reduces plasma PGE2 levels[1].
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GK470 | GK470 (compound 28) is an inhibitor of group IVA cytosolic phospholipase A2 (GIVA cPLA2) with an IC50 of 300 nM in vesicle assays. GK470 has anti-inflammatory activity, inhibiting the release of arachidonic acid in SW982 fibroblast-like synoviocytes with an IC50 value of 0.6 μM. GK470 exhibits comparable anti-inflammatory effects to Methotrexate (HY-14519) in a preventive collagen-induced arthritis model and significantly reduces plasma PGE2 levels. | |||||||||||||||||||||
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Keywords
