GLS1 Inhibitor-1

製品番号: HY-136704 純度: 98.59%: Data Sheet SDS COA 取扱説明書
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GLS1 Inhibitor-1 (Compound 27) is an orally active inhibitor for glutaminase 1 (GLS1) with an IC₅₀ of 0.021 μM. GLS1 Inhibitor-1 inhibits the proliferation of PC-3 with an IC₅₀ of 0.3 nM. GLS1 Inhibitor-1 exhibits antitumor efficacy against NCI-H1703 with GI₅₀ of 0.011 μM. GLS1 Inhibitor-1 exhibits moderate pharmacokinetic characteristics.

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GLS1 Inhibitor-1 構造式

CAS 番号 : 1832646-52-2

容量	価格（税別）	在庫状況	数量
5 mg	$215	在庫あり	Estimated Time of Arrival: December 31
10 mg	$350	在庫あり	Estimated Time of Arrival: December 31
50 mg		お問い合わせ
100 mg		お問い合わせ

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* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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Based on 0 publication(s) in Google Scholar

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製品説明

IC₅₀ & Target

IC₅₀: 0.021 μM (GLS1)

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	> 33.3 3 Compound: 27	Inhibition of human ERG expressed in CHO cells by Ionworks electrophysiology assay Inhibition of human ERG expressed in CHO cells by Ionworks electrophysiology assay	[PMID: 31199640]
CHO	IC₅₀	>33.3 3 Compound: 27	Inhibition of human ERG expressed in CHO cells by Ionworks electrophysiology assay Inhibition of human ERG expressed in CHO cells by Ionworks electrophysiology assay	[PMID: 31199640]
A549	IC₅₀	12.59 1 Compound: 6a	Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by Celltiter-glo assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by Celltiter-glo assay	[PMID: 37849538]
CHO	IC₅₀	> 33.3 3 Compound: 27	Inhibition of human ERG expressed in CHO cells by Ionworks electrophysiology assay Inhibition of human ERG expressed in CHO cells by Ionworks electrophysiology assay	[PMID: 31199640]
NCI-H1703	GI₅₀	0.011 3 Compound: 27	Antiproliferative activity against human NCI-H1703 cells assessed as reduction in cell growth after 5 days by SYTOX green staining-based assay Antiproliferative activity against human NCI-H1703 cells assessed as reduction in cell growth after 5 days by SYTOX green staining-based assay	[PMID: 31199640]
A549	IC₅₀	12.59 1 Compound: 6a	Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by Celltiter-glo assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by Celltiter-glo assay	[PMID: 37849538]
NCI-H1703	GI₅₀	0.011 3 Compound: 27	Antiproliferative activity against human NCI-H1703 cells assessed as reduction in cell growth after 5 days by SYTOX green staining-based assay Antiproliferative activity against human NCI-H1703 cells assessed as reduction in cell growth after 5 days by SYTOX green staining-based assay	[PMID: 31199640]
NCI-H1703	GI₅₀	0.011 3 Compound: 27	Antiproliferative activity against human NCI-H1703 cells assessed as reduction in cell growth after 5 days by SYTOX green staining-based assay Antiproliferative activity against human NCI-H1703 cells assessed as reduction in cell growth after 5 days by SYTOX green staining-based assay	[PMID: 31199640]

分子量

411.48

分子式

C₁₉H₂₁N₇O₂S

CAS 番号

1832646-52-2

Appearance

Solid

Color

White to light yellow

SMILES

O=C([C@H](C1=CC=CC=C1)OC)NC2=NN=C(S2)N[C@H]3CN(C4=CC=CN=N4)CC3

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶剤 & 溶解度

体外:

DMSO : 20 mg/mL (48.61 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4303 mL	12.1513 mL	24.3025 mL
5 mM	0.4861 mL	2.4303 mL	4.8605 mL
10 mM	0.2430 mL	1.2151 mL	2.4303 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 98.59%

Select Batch:

データシート (272 KB) SDS (252 KB)

COA (250 KB) RP-HPLC (75 KB) MS (89 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Finlay MRV, et al., Discovery of a Thiadiazole-Pyridazine-Based Allosteric Glutaminase 1 Inhibitor Series That Demonstrates Oral Bioavailability and Activity in Tumor Xenograft Models. J Med Chem. 2019 Jul 25;62(14):6540-6560. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4303 mL	12.1513 mL	24.3025 mL	60.7563 mL
	5 mM	0.4861 mL	2.4303 mL	4.8605 mL	12.1513 mL
	10 mM	0.2430 mL	1.2151 mL	2.4303 mL	6.0756 mL
	15 mM	0.1620 mL	0.8101 mL	1.6202 mL	4.0504 mL
	20 mM	0.1215 mL	0.6076 mL	1.2151 mL	3.0378 mL
	25 mM	0.0972 mL	0.4861 mL	0.9721 mL	2.4303 mL
	30 mM	0.0810 mL	0.4050 mL	0.8101 mL	2.0252 mL
	40 mM	0.0608 mL	0.3038 mL	0.6076 mL	1.5189 mL

GLS1 Inhibitor-1 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量		濃度		体積		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）	×	体積 _（開始）	=	濃度 _（終了）	×	体積 _（終了）
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GLS1 Inhibitor-11832646-52-2GlutaminaseSCID mousePC-3NCI-H1703orally activeWistar ratInhibitorinhibitorinhibit

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GLS1 Inhibitor-1

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GLS1 Inhibitor-1 関連抗体

おすすめ

•関連スクリーニングライブラリ:

•関連小分子:

•関連タンパク質:

生物活性

純度とドキュメンテーション

参考文献

カスタマーレビュー

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

GLS1 Inhibitor-1 Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

Keywords:

最近チェックした製品:

カスタマーレビュー

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