2. Membrane Transporter/Ion Channel
  3. GLUT
  4. GLUT inhibitor-1

GLUT inhibitor-1 is a potent and orally active inhibitor of glucose transporters, targeting both GLUT1 and GLUT3, with IC50s of 242 nM and 179 nM, respectively. GLUT inhibitor-1 has the potential for the reaesrch of cancers and autoimmune diseases.

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GLUT inhibitor-1

GLUT inhibitor-1 構造式

CAS 番号 : 2421141-40-2

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 508 在庫あり
Solution
10 mM * 1 mL in DMSO USD 508 在庫あり
Solid
1 mg $190 在庫あり
5 mg $420 在庫あり
10 mg $670 在庫あり
25 mg $1340 在庫あり
50 mg $2140 在庫あり
100 mg $3400 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 1 publication(s) in Google Scholar

GLUT inhibitor-1 関連抗体

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GLUT アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
GLUT1 GLUT2 GLUT3 GLUT4

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  • 純度とドキュメンテーション

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製品説明

GLUT inhibitor-1 is a potent and orally active inhibitor of glucose transporters, targeting both GLUT1 and GLUT3, with IC50s of 242 nM and 179 nM, respectively. GLUT inhibitor-1 has the potential for the reaesrch of cancers and autoimmune diseases[1].

IC50 & Target

GLUT1

242 nM (IC50)

GLUT3

179 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
DLD-1 IC50
179 nM
Compound: 15b
Inhibition of GLUT3 in SLC2A1-deficient human DLD1 cells assessed as reduction in ATP level measured after 90 mins by Celltiter-glo luminescent assay
Inhibition of GLUT3 in SLC2A1-deficient human DLD1 cells assessed as reduction in ATP level measured after 90 mins by Celltiter-glo luminescent assay
[PMID: 32282207]
DLD-1 IC50
242 nM
Compound: 15b
Inhibition of GLUT1 in human wild-type DLD1 cells assessed as reduction in ATP level measured after 90 mins by Celltiter-glo luminescent assay
Inhibition of GLUT1 in human wild-type DLD1 cells assessed as reduction in ATP level measured after 90 mins by Celltiter-glo luminescent assay
[PMID: 32282207]
体内実験

Summary of the pharmacokinetic parameters of GLUT inhibitor-1 (compound 15b; 30 mg/kg) in mouse and rat[1].

Parameter Mouse Rat
oral Cmax (ng/mL) 2525 1675
oral AUC (ng/mL) 5890 6813
CL (mL/min/kg) 40 37
Vdss (L/Kg) 1.70 4.51
t1/2 (h) 0.785 2.59
F (%) 45.4 49.4
B/Pb 0.05

b: Solubility is determined in PBS buffer solutions.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

549.67

分子式

C32H35N7O2
CAS 番号
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(COC1=CC=CC(C2=NC(CCN(C3CCC3)C4)=C4C(NC5=CC=C(C6=CNN=C6)C=C5)=N2)=C1)NC7(CC7)C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (181.93 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8193 mL 9.0964 mL 18.1927 mL
5 mM 0.3639 mL 1.8193 mL 3.6385 mL
10 mM 0.1819 mL 0.9096 mL 1.8193 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

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純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8193 mL 9.0964 mL 18.1927 mL 45.4818 mL
5 mM 0.3639 mL 1.8193 mL 3.6385 mL 9.0964 mL
10 mM 0.1819 mL 0.9096 mL 1.8193 mL 4.5482 mL
15 mM 0.1213 mL 0.6064 mL 1.2128 mL 3.0321 mL
20 mM 0.0910 mL 0.4548 mL 0.9096 mL 2.2741 mL
25 mM 0.0728 mL 0.3639 mL 0.7277 mL 1.8193 mL
30 mM 0.0606 mL 0.3032 mL 0.6064 mL 1.5161 mL
40 mM 0.0455 mL 0.2274 mL 0.4548 mL 1.1370 mL
50 mM 0.0364 mL 0.1819 mL 0.3639 mL 0.9096 mL
60 mM 0.0303 mL 0.1516 mL 0.3032 mL 0.7580 mL
80 mM 0.0227 mL 0.1137 mL 0.2274 mL 0.5685 mL
100 mM 0.0182 mL 0.0910 mL 0.1819 mL 0.4548 mL
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GLUT inhibitor-1 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GLUT inhibitor-12421141-40-2GLUT inhibitor1GLUT inhibitor 1GLUTGlucose transporterGLUT1GLUT3oralaerobic glycolysisanti-cancerautoimmuneWarburgglucose transporterInhibitorinhibitorinhibit

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製品名:
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製品番号:
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