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  4. Glyceryl monostearate

Glyceryl monostearate  (Synonyms: GMS)

製品番号: HY-151226 純度: 98.0%
COA 取扱説明書 Technical Support

Glyceryl monostearate (GMS) is a type of monoglyceride. Glyceryl monostearateGlyceryl monostearate can serve as a core lipid material for constructing solid lipid nanoparticles in the field of drug delivery. Glyceryl monostearate can be used as a gelling agent to structure liquid vegetable oils into semi-solid oleogels, so as to replace animal fat in meat products.

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Glyceryl monostearate

Glyceryl monostearate 構造式

CAS 番号 : 31566-31-1

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 27 在庫あり
Solution
10 mM * 1 mL in DMSO USD 27 在庫あり
Solid
100 g $25 在庫あり
> 100 g   お問い合わせ  

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Other Forms of Glyceryl monostearate:

Glyceryl monostearate 関連抗体

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製品説明

Glyceryl monostearate (GMS) is a type of monoglyceride. Glyceryl monostearateGlyceryl monostearate can serve as a core lipid material for constructing solid lipid nanoparticles in the field of drug delivery. Glyceryl monostearate can be used as a gelling agent to structure liquid vegetable oils into semi-solid oleogels, so as to replace animal fat in meat products[1][2].

Cellular Effect
Cell Line Type Value Description References
LNCaP IC50
>100 3
Compound: 8
Cytotoxicity against human LNCAP cells after 48 hrs by MTT assay
Cytotoxicity against human LNCAP cells after 48 hrs by MTT assay
[PMID: 11858758]
NUGC-3 IC50
100 3
Compound: MG
Cytotoxicity against human NUGC-3 cells assessed as cell growth inhibition incubated for 30 mins by MTT assay
Cytotoxicity against human NUGC-3 cells assessed as cell growth inhibition incubated for 30 mins by MTT assay
[PMID: 29126728]
体外実験

Glyceryl monostearate is used in solid lipid nanoparticles for the controlled-release delivery of Docetaxel (HY-B0011) to enhance its therapeutic efficacy, and these nanoparticles can be applied to research on breast cancer and ovarian cancer[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Glyceryl monostearate 関連抗体
分子量

358.56

分子式

C21H42O4
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCCCCCCCCCCCC(OCC(CO)O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Store at room temperature 3 years

*In solvent : -80°C, 6 months; -20°C, 1 month (Store at room temperature 3 years)
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (278.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7889 mL 13.9447 mL 27.8893 mL
5 mM 0.5578 mL 2.7889 mL 5.5779 mL
10 mM 0.2789 mL 1.3945 mL 2.7889 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 5 mg/mL (13.94 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション

純度: 98.0%

COA (237 KB) HNMR (292 KB) LCMS (95 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7889 mL 13.9447 mL 27.8893 mL 69.7233 mL
5 mM 0.5578 mL 2.7889 mL 5.5779 mL 13.9447 mL
10 mM 0.2789 mL 1.3945 mL 2.7889 mL 6.9723 mL
15 mM 0.1859 mL 0.9296 mL 1.8593 mL 4.6482 mL
20 mM 0.1394 mL 0.6972 mL 1.3945 mL 3.4862 mL
25 mM 0.1116 mL 0.5578 mL 1.1156 mL 2.7889 mL
30 mM 0.0930 mL 0.4648 mL 0.9296 mL 2.3241 mL
40 mM 0.0697 mL 0.3486 mL 0.6972 mL 1.7431 mL
50 mM 0.0558 mL 0.2789 mL 0.5578 mL 1.3945 mL
60 mM 0.0465 mL 0.2324 mL 0.4648 mL 1.1621 mL
80 mM 0.0349 mL 0.1743 mL 0.3486 mL 0.8715 mL
100 mM 0.0279 mL 0.1394 mL 0.2789 mL 0.6972 mL
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Glyceryl monostearate Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glyceryl monostearate31566-31-1GMSLiposomeEnvironmental PollutantsEnvironmental Contaminantspork fatunsaturated fatty acidsaturated fatty acidovarian cancersunflower oildocetaxelBologna sausagesbreast cancersolid lipid nanoparticleshigh oleic sunflower oilInhibitorinhibitorinhibit

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製品名:
Glyceryl monostearate
製品番号:
HY-151226
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