2. Anti-infection
  3. HIV
  4. gp120-IN-1

gp120-IN-1 (compound 4e) is a potent HIV-1 gp120 inhibitor with an IC50 of 2.2 µM and CC50 of 100.90 µM. gp120-IN-1 shows anti-HIV-1 activity. gp120-IN-1 shows cytotoxicity in a dose dependent manner in SUP-T1 cells. gp120-IN-1 shows inhibition of gp120-mediated virus enter into cells.

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gp120-IN-1

gp120-IN-1 構造式

CAS 番号 : 5948-75-4

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gp120-IN-1 関連抗体

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製品説明

gp120-IN-1 (compound 4e) is a potent HIV-1 gp120 inhibitor with an IC50 of 2.2 µM and CC50 of 100.90 µM. gp120-IN-1 shows anti-HIV-1 activity. gp120-IN-1 shows cytotoxicity in a dose dependent manner in SUP-T1 cells. gp120-IN-1 shows inhibition of gp120-mediated virus enter into cells[1].

IC50 & Target[1]

HIV-1

2.2 μM (IC50)

HIV-1

100.90 μM (CC50)

Cellular Effect
Cell Line Type Value Description References
786-0 GI50
30 μg/mL
Compound: BA21
Growth inhibition of human 786-0 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human 786-0 cells after 48 hrs by sulforhodamine B assay
[PMID: 22410248]
A549 IC50
> 100 μM
Compound: 4
Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay
[PMID: 31673316]
HCT-116 IC50
> 100 μM
Compound: 4
Antiproliferative activity against human HCT116 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human HCT116 cells incubated for 72 hrs by MTT assay
[PMID: 31673316]
HT-29 GI50
34.9 μg/mL
Compound: BA21
Growth inhibition of human HT-29 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human HT-29 cells after 48 hrs by sulforhodamine B assay
[PMID: 22410248]
MCF7 IC50
> 100 μM
Compound: 4
Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay
[PMID: 31673316]
MM1.S IC50
> 100 μM
Compound: 4
Antiproliferative activity against human MM1S cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human MM1S cells incubated for 72 hrs by MTT assay
[PMID: 31673316]
NCI-H460 GI50
180.4 μg/mL
Compound: BA21
Growth inhibition of human NCI-H460 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human NCI-H460 cells after 48 hrs by sulforhodamine B assay
[PMID: 22410248]
NCI/ADR-RES GI50
59.7 μg/mL
Compound: BA21
Growth inhibition of human NCI-ADR-RES cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human NCI-ADR-RES cells after 48 hrs by sulforhodamine B assay
[PMID: 22410248]
OVCAR-3 GI50
11 μg/mL
Compound: BA21
Growth inhibition of human OVCAR3 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human OVCAR3 cells after 48 hrs by sulforhodamine B assay
[PMID: 22410248]
PC-3 GI50
72.6 μg/mL
Compound: BA21
Growth inhibition of human PC3 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human PC3 cells after 48 hrs by sulforhodamine B assay
[PMID: 22410248]
SUP-T1 CC50
100.9 μM
Compound: 4e
Cytotoxicity against human SUP-T1 cells assessed as reduction in cell viability measured after 16 hrs by MTT assay
Cytotoxicity against human SUP-T1 cells assessed as reduction in cell viability measured after 16 hrs by MTT assay
[PMID: 34839157]
U-251 GI50
88.3 μg/mL
Compound: BA21
Growth inhibition of human U251 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human U251 cells after 48 hrs by sulforhodamine B assay
[PMID: 22410248]
分子量

322.38

分子式

C15H18N2O4S
CAS 番号
SMILES

CCOC(C1=C(NC(NC1C2=CC(OC)=C(C=C2)O)=S)C)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
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gp120-IN-1 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

gp120-IN-15948-75-4HIVHuman immunodeficiency virusSupT1 cellslow cytotoxicityanti-HIV-1HL2/3dose-dependent mannerInhibitorinhibitorinhibit

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製品名:
gp120-IN-1
製品番号:
HY-144730
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