HEMADO 

HEMADO is a potent and selective adenosine A₃ receptor agonist with a K_i of 1.1 nM at the human A₃ subtype^[1]. HEMADO is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Ki: 1.1 nM (human A₃ subtype)^[1]

HEMADO (compound 8a) has K_is of 327 nM and 1230 nM for A₁ and A_2A and a EC₅₀ of 100 μM for A_2B receptors^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

361.40

C₁₇H₂₃N₅O₄

403842-38-6

Solid

White to off-white

OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3=C2N=C(C#CCCCC)N=C3NC)O1)O)O

Room temperature in continental US; may vary elsewhere.

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Klotz KN, et al. [3H]HEMADO— a novel tritiated agonist selective for the human adenosine A3 receptor. Eur J Pharmacol. 2007 Feb 5;556(1-3):14-8. Epub 2006 Oct 27.  [Content Brief]

  [2]. Volpini R, et al. N(6)-alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A(3) receptor and a starting point for searching A(2B) ligands. J Med Chem. 2002 Jul 18;45(15):3271-9.  [Content Brief]