2. Inhibitory Antibodies
  3. Isotype Control Antibodies
  4. Human IgG4 (S228P) kappa, Isotype Control

Human IgG4 (S228P) kappa, Isotype Control 

Cat. No.: HY-P99003 Purity: 99.35%
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Human IgG4 (S228P) kappa, Isotype Control, a human-derived monoclonal antibody, is an isotype control for human IgG4κ antibody.

For research use only. We do not sell to patients.

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Customer Review

Based on 9 publication(s) in Google Scholar

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Human IgG4 (S228P) kappa, Isotype Control Related Antibodies

Top Publications Citing Use of Products

    Human IgG4 (S228P) kappa, Isotype Control purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Nov 24.

    Isotype control antibodies (IgG4κ and IgG1κ) were used as negative controls to demonstrate that pembrolizumab (anti-PD-1) and fragifilimab (anti-GITR) showed no inhibition of tumor growth in the HU-CD34+ T188 PDOX mouse model.

    Human IgG4 (S228P) kappa, Isotype Control purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Aug 7;15(1):6726.  [Abstract]

    An isotype control antibody (IgG4, κ, solid circles, 0–80 µg/ml, 25 h) was used as a negative control to demonstrate that the dose-dependent blockade of SHFV infection in MA-104 cells was specifically mediated by orilanolimab (open circles).

    Human IgG4 (S228P) kappa, Isotype Control purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Aug 7;15(1):6726.  [Abstract]

    Human IgG4 (S228P) kappa isotype control (80 µg/ml, 24h) was used as a negative control to demonstrate that the blockade of SHFV infection was specifically mediated by orilanolimab across multiple cell types, including uninfected cells, wild-type MA-104 cells, ACHN+hCD163 cells, and macaque iPSC-derived macrophages.

    Human IgG4 (S228P) kappa, Isotype Control purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Aug 7;15(1):6726.  [Abstract]

    Human IgG4 (S228P) kappa isotype control (80 µg/ml, 24 h) was used as a negative control to demonstrate that orilanolimab reduced the replication of SHFV, KRCV-1, and PBJV.

    Human IgG4 (S228P) kappa, Isotype Control purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Aug 7;15(1):6726.  [Abstract]

    Human IgG4 (S228P) kappa isotype control (80 µg/ml, 24 h) was used as a negative control to demonstrate that orilanolimab enhanced the overall survivability of macaque iPSC-derived macrophages in the presence of arteriviruses.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Human IgG4 (S228P) kappa, Isotype Control, a human-derived monoclonal antibody, is an isotype control for human IgG4κ antibody.

    In Vitro

    Human IgG4 (S228P) kappa, Isotype Control is often used as the experimental negative control. Human IgG4 (S228P) kappa, Isotype Control exhibits similar structure and biological properties as human immunoglobulin G4 (IgG4), but lacks specific antigen binding ability[2].
    Human IgG4 (S228P) kappa, Isotype Control (80 μg/mL, 1 h) exhibits no resistant effects against KRCV-1 and PBJV infection in MA-104 cell (Orilanolimab (HY-P99791) is used as the control in the experiment)[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Human IgG4 (S228P) kappa, Isotype Control Related Antibodies
    Application

    ELISA, FACS, Functional assay
    Conjugated

    Unconjugated
    Reconsititution

    The product can be reconstituted/diluted with sterile PBS or saline.
    Molecular Weight

    142.35 kDa

    Appearance

    Liquid

    Color

    Colorless to light yellow

    SMILES

    [Human IgG4 (S228P) kappa, Isotype Control]
    Shipping

    Shipping with dry ice.
    Formulation

    Please refer to the lot-specific COA for specific buffer information.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation

    Purity: 99.35%

    SDS (251 KB)

    COA (232 KB) SDS-PAGE (90 KB) SEC-HPLC (136 KB)

    Inhibitory Antibodies User Guide (603 KB)
    References
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    Human IgG4 (S228P) kappa, Isotype Control Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Human IgG4 (S228P) kappa, Isotype ControlOthershumanizedmonoclonalantibodyIgG4κInhibitorinhibitorinhibit

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