Hypoxanthine-d₄

Art. -Nr.: HY-N0091S5 Reinheit: 99.70%: Data Sheet
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Hypoxanthine-d₄ is the deuterium labeled Hypoxanthine. Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia.

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Hypoxanthine-d₄ Chemische Struktur

CAS. Nr. : 2483831-32-7

Größe	Verfügbarkeit	Menge
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	Angebot einholen 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	Angebot einholen 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks	Estimated Time of Arrival: December 31
Solid
10 mg	Auf Lager	Estimated Time of Arrival: December 31
50 mg	Angebot einholen
100 mg	Angebot einholen

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This product is a controlled substance and not for sale in your territory.

Other Forms of Hypoxanthine-d₄:

Hypoxanthine In-stock

Spezialitätsempfehlungen

•Related Small Molecules:

•Related Proteins:

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen:

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Human Endogenous Metabolite Microbial Metabolite

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Beschreibung

Hypoxanthine-d₄ is the deuterium labeled Hypoxanthine^[1]. Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia^[2].

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molekulargewicht

140.14

Formel

C₅D₄N₄O

CAS. Nr.

2483831-32-7

Unlabeled CAS

68-94-0

Appearance

Solid

Color

White to off-white

SMILES

O=C1C2=C(N=C([2H])N2[2H])N([2H])C([2H])=N1

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 10 mg/mL (71.36 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.1357 mL	35.6786 mL	71.3572 mL
5 mM	1.4271 mL	7.1357 mL	14.2714 mL
10 mM	0.7136 mL	3.5679 mL	7.1357 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Reinheit & Dokumentation

Purity: 99.70%

Select Batch:

Data Sheet (273 KB) SDS (252 KB)

COA (250 KB) HNMR (603 KB) RP-HPLC (910 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]

[2]. Saugstad OD, et al. Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production. Pediatr Res. 1988 Feb;23(2):143-50. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	7.1357 mL	35.6786 mL	71.3572 mL	178.3930 mL
	5 mM	1.4271 mL	7.1357 mL	14.2714 mL	35.6786 mL
	10 mM	0.7136 mL	3.5679 mL	7.1357 mL	17.8393 mL
	15 mM	0.4757 mL	2.3786 mL	4.7571 mL	11.8929 mL
	20 mM	0.3568 mL	1.7839 mL	3.5679 mL	8.9197 mL
	25 mM	0.2854 mL	1.4271 mL	2.8543 mL	7.1357 mL
	30 mM	0.2379 mL	1.1893 mL	2.3786 mL	5.9464 mL
	40 mM	0.1784 mL	0.8920 mL	1.7839 mL	4.4598 mL
	50 mM	0.1427 mL	0.7136 mL	1.4271 mL	3.5679 mL
	60 mM	0.1189 mL	0.5946 mL	1.1893 mL	2.9732 mL