IBMX  (Synonyms: 3-Isobutyl-1-methylxanthine; Isobutylmethylxanthine)

IBMX (3-Isobutyl-1-methylxanthine) (GMP) is IBMX (HY-12318) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. IBMX is a broad-spectrum phosphodiesterase (PDE) inhibitor^{[1][2][3][4][5]}.

IBMX (0.5 mM) induces neural-like cells for neural differentiation of cord blood derived mesenchymal-like stem cells^[1].
IBMX induces initiation of the differentiation of programpre-adipocytes^[2].
IBMX (500 μM) induces neuronal differentiation of small cell lung cancer^[3].
IBMX (100 μM) induces differentiation of 3T3-LI adipocytes^[4].
IBMX (500 μM) induces adipose tissue-derived stem cells (ADSC) differentiate into neuron-like cells^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

222.24

C₁₀H₁₄N₄O₂

28822-58-4

Solid

White to off-white

O=C(N1C)N(CC(C)C)C2=C(N=CN2)C1=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Tio M, et al. Roles of db-cAMP, IBMX and RA in aspects of neural differentiation of cord blood derived mesenchymal-like stem cells. PLoS One. 2010 Feb 24;5(2):e9398.  [Content Brief]

  [2]. Kim SP, et al. Transcriptional activation of peroxisome proliferator-activated receptor-gamma requires activation of both protein kinase A and Akt during adipocyte differentiation. Biochem Biophys Res Commun. 2010 Aug 13;399(1):55-9.  [Content Brief]

  [3]. Lange A, et al. Neuronal differentiation by indomethacin and IBMX inhibits proliferation of small cell lung cancer cells in vitro. Lung Cancer. 2011 Nov;74(2):178-87.  [Content Brief]

  [4]. Elks ML, Manganiello VC. A role for soluble cAMP phosphodiesterases in differentiation of 3T3-L1 adipocytes. J Cell Physiol. 1985 Aug;124(2):191-8.  [Content Brief]

  [5]. Ning H, et al. Insulin growth factor signaling mediates neuron-like differentiation of adipose-tissue-derived stem cells. Differentiation. 2008 May;76(5):488-94.  [Content Brief]