1. Anti-infection
  2. Fungal
  3. iKIX1

iKIX1 

Cat. No.: HY-124952
Handling Instructions

iKIX1 is an antifungal agent and re-sensitizes drug-resistant C. glabrata to azole antifungals in vitro. iKIX1 inhibits the interaction between the KIX domain of the mediator subunit CgGal11A and the activation domain of CgPdr1, the IC50 and Ki values are 190.2 μM and 18 μM, respectively. iKIX1 is used for the study of multidrug resistance and C. glabrata infection.

For research use only. We do not sell to patients.

iKIX1 Chemical Structure

iKIX1 Chemical Structure

CAS No. : 656222-54-7

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Description

iKIX1 is an antifungal agent and re-sensitizes drug-resistant C. glabrata to azole antifungals in vitro. iKIX1 inhibits the interaction between the KIX domain of the mediator subunit CgGal11A and the activation domain of CgPdr1, the IC50 and Ki values are 190.2 μM and 18 μM, respectively. iKIX1 is used for the study of multidrug resistance and C. glabrata infection[1].

IC50 & Target

IC50: 190.2 μM (interaction between CgGal11A and CgPdr1)
Ki: 18 μM (interaction between CgGal11A and CgPdr1)[1]

Molecular Weight

303.17

Formula

C₁₀H₈Cl₂N₄OS

CAS No.

656222-54-7

SMILES

O=C(NNC(NC1=CC=C(Cl)C(Cl)=C1)=S)CC#N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

iKIX1iKIX 1iKIX-1FungalantifungalC. glabratainfectionCgGal11ACgPdr1drug-resistantInhibitorinhibitorinhibit

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