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Cat. No.: HY-184289

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KJ001-12a

KJ001-12a is an orally active anti-influenza agent with activity against influenza A and B strains. KJ001-12a acts as an RNA-dependent RNA polymerase inhibitor that reduces the expression levels of viral M2 mRNA and vRNA. KJ001-12a shows low sensitivity to the loss of inhibitory activity caused by the I38T mutation. KJ001-12a is applicable for influenza-related research.

For research use only. We do not sell to patients.

Formula: C₂₅H₁₉F₂N₃O₄
Molecular Weight:463.43

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

KJ001-12a Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

RNA Polymerase

All DNA/RNA Synthesis Isoforms :

In Vitro

KJ001-12a potently inhibits influenza A/PR/8/34 (H1N1) replication in MDCK cells with an IC₅₀ of 1.9 nM and a high selectivity index of 6436.8^[1].
KJ001-12a (72 h) inhibits replication of multiple influenza A and B strains in MDCK cells, with IC₅₀ values ranging from 15.56 nM to 59.26 nM and a consistent TC₅₀ of 12.23 μM^[1].
KJ001-12a inhibits influenza A/PR/8/34 (WT) replication in MDCK cells with an IC₅₀ of 25.72 nM, and its activity is reduced only 9.36-fold against the I38T mutant strain^[1].
KJ001-12a (0.2 nM; 24 h) significantly inhibits influenza A/PR/8/34 (H1N1) M2 mRNA expression in MDCK cells, achieving a 76.72% inhibition rate^[1].
KJ001-12a (1-10 nM) dose-dependently inhibits influenza A virus RdRp activity in 293T cells, achieving 45.6% inhibition at 10 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	T_1/2	T_max	C_max	AUC_0-t	AUC_0-∞	MRT_0-t	CL	F
Rat^[1]	1.00 mg/kg	i.v.	1.90 h	0.08 h	291.94 ng/mL	359.16 ng·h/mL	369.73 ng·h/mL	1.41 h	2718.58 mL/h/kg	/
Rat^[1]	5.00 mg/kg	p.o.	0.94 h	1.00 h	256.10 ng/mL	722.77 ng·h/mL	726.46 ng·h/mL	1.80 h	/	40.25 %

In Vivo

KJ001-12a (1-5 mg/kg; i.v., p.o.; single dose) exhibits an absolute oral bioavailability of 40.25% in male Sprague-Dawley rats, with favorable pharmacokinetic parameters after single intravenous and oral doses^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 463.43
Formula C₂₅H₁₉F₂N₃O₄
SMILES

O=C1N2[C@](COCC2)([H])N(C3C4=CC=C(F)C=C4C=CC5=CC(F)=CC=C35)N6C1=C(O)C(C=C6)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhu C, et al.. Design, synthesis, and evaluation of polycyclic pyridone derivatives as potent influenza inhibitors. Bioorganic chemistry. 2026 Jun 04;180:110037. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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