KRAS G12C inhibitor 15

製品番号: HY-125873 純度: 98.47%: Data Sheet SDS COA 取扱説明書
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KRAS G12C inhibitor 15 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 22, has an IC₅₀ of 5 nM.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

KRAS G12C inhibitor 15 構造式

CAS 番号 : 2349393-21-9

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 840	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 840	在庫あり	Estimated Time of Arrival: December 31
Solid
1 mg	$310	在庫あり	Estimated Time of Arrival: December 31
5 mg	$765	在庫あり	Estimated Time of Arrival: December 31
10 mg	$1225	在庫あり	Estimated Time of Arrival: December 31
25 mg	$2213	在庫あり	Estimated Time of Arrival: December 31
50 mg	$3320	在庫あり	Estimated Time of Arrival: December 31
100 mg	$4980	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 0 publication(s) in Google Scholar

Ras アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

K-Ras H-Ras N-Ras Ras

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

KRAS G12C inhibitor 15 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 22, has an IC₅₀ of 5 nM^[1].

IC₅₀ & Target^[1]

KRas G12C

5 nM (IC₅₀)

分子量

498.91

分子式

C₂₅H₂₁ClF₂N₄O₃

CAS 番号

2349393-21-9

Appearance

Solid

Color

White to yellow

SMILES

FC1=C(N=CC(N2C)=C3N4[C@H](CN(C(C=C)=O)[C@H](C)C4)C2=O)C3=CC(Cl)=[C@@]1[C@@]5=C(F)C=CC=C5O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

溶剤 & 溶解度

体外:

DMSO : 193.33 mg/mL (387.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0044 mL	10.0218 mL	20.0437 mL
5 mM	0.4009 mL	2.0044 mL	4.0087 mL
10 mM	0.2004 mL	1.0022 mL	2.0044 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 98.47%

Select Batch:

データシート (275 KB) SDS (252 KB)

COA (257 KB) RP-HPLC (257 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Jason Grant Kettle, et al. Tetracyclic compounds as inhibitors of g12c mutant ras protein, for use as anti-cancer agents. WO2019110751A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.0044 mL	10.0218 mL	20.0437 mL	50.1092 mL
	5 mM	0.4009 mL	2.0044 mL	4.0087 mL	10.0218 mL
	10 mM	0.2004 mL	1.0022 mL	2.0044 mL	5.0109 mL
	15 mM	0.1336 mL	0.6681 mL	1.3362 mL	3.3406 mL
	20 mM	0.1002 mL	0.5011 mL	1.0022 mL	2.5055 mL
	25 mM	0.0802 mL	0.4009 mL	0.8017 mL	2.0044 mL
	30 mM	0.0668 mL	0.3341 mL	0.6681 mL	1.6703 mL
	40 mM	0.0501 mL	0.2505 mL	0.5011 mL	1.2527 mL
	50 mM	0.0401 mL	0.2004 mL	0.4009 mL	1.0022 mL
	60 mM	0.0334 mL	0.1670 mL	0.3341 mL	0.8352 mL
	80 mM	0.0251 mL	0.1253 mL	0.2505 mL	0.6264 mL
	100 mM	0.0200 mL	0.1002 mL	0.2004 mL	0.5011 mL