[Leu15]-Gastrin I (human)

Name: [Leu15]-Gastrin I (human)
Brand: MedChemExpress
SKU: HY-P2671
Rating: 4.5 (0 reviews)

Art. -Nr.: HY-P2671 Reinheit: 99.98%: Data Sheet
COA

SDS
Handling Instructions
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[Leu15]-Gastrin I (human) is a Gastrin I, human (HY-P1097) peptide hormone derivative, which is trophic for normal gastrointestinal epithelium. Gastrin stimulates growth of gastric adenocarcinoma (gastric cancer) through G-protein-coupled receptor called the cholecystokinin (CCK) or cholecystokinin-B receptors (CCK-BR) that are overexpressed in this malignancy. [Leu15]-Gastrin I (human) is promising for research of gastric cancer.

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Kundenspezifische Peptidsynthese

[Leu15]-Gastrin I (human) Chemische Struktur

CAS. Nr. : 39024-57-2

Größe	Verfügbarkeit	Menge
1 mg	Auf Lager	Estimated Time of Arrival: December 31
5 mg	Auf Lager	Estimated Time of Arrival: December 31
10 mg	Auf Lager	Estimated Time of Arrival: December 31
50 mg	Angebot einholen
100 mg	Angebot einholen

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Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Alle Cholecystokinin Receptor Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

CCKAR CCKBR

Biologische Aktivität
Reinheit & Dokumentation
Verweise
Kundenbewertung

Beschreibung

In Vitro

[Leu15]-Gastrin I (human) detects high concentrations of CCK-B gastrin receptors in the human gastric mucosal glands^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molekulargewicht

2080.16

Formel

C₉₈H₁₂₆N₂₀O₃₁

CAS. Nr.

39024-57-2

Appearance

Solid

Color

White to off-white

Sequence

{Pyr}-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Leu-Asp-Phe-NH2

Sequence Shortening

{Pyr}-GPWLEEEEEAYGWLDF-NH2

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Sealed storage, away from moisture and light

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (48.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 10.53 mg/mL (5.06 mM; ultrasonic and adjust pH to 11 with NaOH)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.4807 mL	2.4037 mL	4.8073 mL
5 mM	0.0961 mL	0.4807 mL	0.9615 mL
10 mM	0.0481 mL	0.2404 mL	0.4807 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Reinheit & Dokumentation

Purity: 99.98%

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Data Sheet (274 KB) SDS (252 KB)

COA (248 KB) RP-HPLC (216 KB) MS (68 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Kleomenis Barlos, et al. Veresterung von partiell geschützten peptid-fragmenten mit harzen. Einsatz von 2-chlortritylchlorid zur synthese von Leu15 -gastrin I[J]. Tetrahedron Letters, 1989.

[2]. Smith JP, et al. Gastrin and Gastric Cancer. Cell Mol Gastroenterol Hepatol. 2017 Mar 14;4(1):75-83. [Content Brief]

[3]. Barlos K, et al. Application of 2-chlorotrityl resin in solid phase synthesis of (Leu15)-gastrin I and unsulfated cholecystokinin octapeptide. Selective O-deprotection of tyrosine. Int J Pept Protein Res. 1991 Dec;38(6):555-61. [Content Brief]

[4]. Reubi JC, et al. Localization of cholecystokinin A and cholecystokinin B-gastrin receptors in the human stomach. Gastroenterology. 1997 Apr;112(4):1197-205. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	0.4807 mL	2.4037 mL	4.8073 mL	12.0183 mL
H₂O / DMSO	5 mM	0.0961 mL	0.4807 mL	0.9615 mL	2.4037 mL
DMSO	10 mM	0.0481 mL	0.2404 mL	0.4807 mL	1.2018 mL
	15 mM	0.0320 mL	0.1602 mL	0.3205 mL	0.8012 mL
	20 mM	0.0240 mL	0.1202 mL	0.2404 mL	0.6009 mL
	25 mM	0.0192 mL	0.0961 mL	0.1923 mL	0.4807 mL
	30 mM	0.0160 mL	0.0801 mL	0.1602 mL	0.4006 mL
	40 mM	0.0120 mL	0.0601 mL	0.1202 mL	0.3005 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.