2. Others Protein Tyrosine Kinase/RTK JAK/STAT Signaling Epigenetics Stem Cell/Wnt
  3. Isotope-Labeled Compounds JAK
  4. Lomedeucitinib

Lomedeucitinib (BMS-986322) is a tyrosine protein kinase (TYK2) inhibitor.

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Lomedeucitinib

Lomedeucitinib Estructura química

No. CAS : 2328068-29-5

Tamaño Precio Stock Cantidad
1 mg Obtener un presupuesto 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks
5 mg En stock
10 mg Obtener un presupuesto 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks
50 mg   Obtener un presupuesto  
100 mg   Obtener un presupuesto  

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Based on 1 Customer Validation

Other Forms of Lomedeucitinib:

Lomedeucitinib Related Antibodies

Top Publications Citing Use of Products

Ver todos los productos específicos de isoformas JAK:

Ver todas las isoformas
JAK1 JAK2 JAK3 Tyk2 JAK

  • Actividad biológica

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Descripciòn

Lomedeucitinib (BMS-986322) is a tyrosine protein kinase (TYK2) inhibitor[1][2][3].

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

IC50 & Target

Tyk2

 

In Vitro

Lomedeucitinib has anti-inflammatory activity and can be used for the study of psoriasis[1][2][3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lomedeucitinib Related Antibodies
Ensayo clínico
Peso molecular

419.47

Fòrmula

C18H17D3N6O4S
No. CAS
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=NN=C(NC([C@@H]2CC23CC3)=O)C=C1NC4=NC=CC=C4S(=O)(C)=O)NC([2H])([2H])[2H]
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvente y solubilidad
In Vitro: 

DMSO : 100 mg/mL (238.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3840 mL 11.9198 mL 23.8396 mL
5 mM 0.4768 mL 2.3840 mL 4.7679 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3840 mL 11.9198 mL 23.8396 mL 59.5990 mL
5 mM 0.4768 mL 2.3840 mL 4.7679 mL 11.9198 mL
10 mM 0.2384 mL 1.1920 mL 2.3840 mL 5.9599 mL
15 mM 0.1589 mL 0.7947 mL 1.5893 mL 3.9733 mL
20 mM 0.1192 mL 0.5960 mL 1.1920 mL 2.9800 mL
25 mM 0.0954 mL 0.4768 mL 0.9536 mL 2.3840 mL
30 mM 0.0795 mL 0.3973 mL 0.7947 mL 1.9866 mL
40 mM 0.0596 mL 0.2980 mL 0.5960 mL 1.4900 mL
50 mM 0.0477 mL 0.2384 mL 0.4768 mL 1.1920 mL
60 mM 0.0397 mL 0.1987 mL 0.3973 mL 0.9933 mL
80 mM 0.0298 mL 0.1490 mL 0.2980 mL 0.7450 mL
100 mM 0.0238 mL 0.1192 mL 0.2384 mL 0.5960 mL
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Lomedeucitinib Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lomedeucitinib2328068-29-5BMS-986322BMS986322BMS 986322Isotope-Labeled CompoundsJAKJanus kinasepsoriasisInhibitorinhibitorinhibit

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Inquiry Information

Nombre del producto:
Lomedeucitinib
Cat. No.:
HY-160144S
Cantidad:
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