2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. LY255582

LY255582 is a pan-opioid antagonist and has high affinity for mu, delta, and kappa receptors (Ki: 0.4 nM, 5.2, 2.0 nM respectively). LY255582 can decrease food intake and body weight. LY255582 can be used for the research of obesity.

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LY255582

LY255582 Chemical Structure

CAS No. : 119193-09-8

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LY255582 Related Antibodies

Top Publications Citing Use of Products

Voir tous les produits spécifiques à Isoform Opioid Receptor:

Voir toutes les isoformes
μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

  • Activité biologique

  • Pureté et documentation

  • Références

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Description

LY255582 is a pan-opioid antagonist and has high affinity for mu, delta, and kappa receptors (Ki: 0.4 nM, 5.2, 2.0 nM respectively). LY255582 can decrease food intake and body weight. LY255582 can be used for the research of obesity[1][2][3][4].

IC50 & Target[1]

μ Opioid Receptor/MOR

0.4 nM (Ki)

δ Opioid Receptor/DOR

5.2 nM (Ki)

κ Opioid Receptor/KOR

2.0 nM (Ki)

In Vitro

LY255582 (40 μM, 24-72 h) reduces cell viability of Huh7 and MHCC-97H cells[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LY255582 Related Antibodies
In Vivo

LY255582 (100 μg, i.c.v.) reduced food intake in rats[1].
LY255582 (15 mg/kg, s.c., once daily) decreases food intake and body weight gain of fed obese Zucker rats[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: STZ-induced diabetic mice[1]
Dosage: 100, 10 and 1 μg
Administration: i.c.v.
Result: Decreased food at 100, 10 and 1 μg by 76, 62 and 29%.
Masse moléculaire

345.52

Formule

C22H35NO2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1=CC([C@]2([C@H](CN(CC2)CC[C@@H](C3CCCCC3)O)C)C)=CC=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

-20°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvant et solubilité
In Vitro: 

DMSO : 15 mg/mL (43.41 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8942 mL 14.4709 mL 28.9419 mL
5 mM 0.5788 mL 2.8942 mL 5.7884 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculateur de molarité

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureté et documentation

Purity: 98%

SDS (252 KB)

COA (245 KB)

Instruction de manipulation (2659 KB)
Références

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8942 mL 14.4709 mL 28.9419 mL 72.3547 mL
5 mM 0.5788 mL 2.8942 mL 5.7884 mL 14.4709 mL
10 mM 0.2894 mL 1.4471 mL 2.8942 mL 7.2355 mL
15 mM 0.1929 mL 0.9647 mL 1.9295 mL 4.8236 mL
20 mM 0.1447 mL 0.7235 mL 1.4471 mL 3.6177 mL
25 mM 0.1158 mL 0.5788 mL 1.1577 mL 2.8942 mL
30 mM 0.0965 mL 0.4824 mL 0.9647 mL 2.4118 mL
40 mM 0.0724 mL 0.3618 mL 0.7235 mL 1.8089 mL
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LY255582 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LY255582119193-09-8LY 255582LY-255582Opioid ReceptorObesityfood intakebody weightHuh7MHCC-97HInhibitorinhibitorinhibit

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