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  3. Toll-like Receptor (TLR)
  4. Magnesium citrate

Magnesium citrate  (Synonyms: Trimagnesium dicitrate)

Cat. No.: HY-W105835 Pureté: 98.0%
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Magnesium citrate (Trimagnesium dicitrate) is an orally active magnesium-containing compound that can cross the blood-brain barrier (BBB). Magnesium citrate can be used as an intestinal cleanser and is studied for its application in laxatives. Magnesium citrate can also increase the pain threshold and is studied for pain-relief purposes.

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Magnesium citrate

Magnesium citrate Chemical Structure

CAS No. : 3344-18-1

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100 mg En stock
500 mg En stock
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5 g   Obtenir un devis  

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Magnesium citrate Related Antibodies

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Description

Magnesium citrate (Trimagnesium dicitrate) is an orally active magnesium-containing compound that can cross the blood-brain barrier (BBB). Magnesium citrate can be used as an intestinal cleanser and is studied for its application in laxatives. Magnesium citrate can also increase the pain threshold and is studied for pain-relief purposes[1][2].

IC50 & Target[1]

TLR4

 

In Vivo

Magnesium citrate (66 mg/kg; oral gavage; single dose) can increase the pain threshold in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Balb-c mice[1]
Dosage: 66 mg/kg
Administration: Oral gavage; single dose
Result: Increased the pain threshold of mice, especially 4 hours after administration.
Decreased motor conduction velocity decreased in the early stage (4-8 hours) and then increased at 24 hours.
Decreased forelimb grip strength at 4, 8, and 24 hours.
Increased locomotor activity at 4 and 8 hours in the open-field test.
Decreased TLR4 expression in the brain, increased TLR4 expression in the sciatic nerve, and caused no significant change in the dorsal root ganglia and muscle tissue.
Essai clinique
Masse moléculaire

451.11

Formule

C12H10Mg3O14
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.[Mg+2].[Mg+2].[Mg+2]
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvant et solubilité
In Vitro: 

H2O : 4.72 mg/mL (10.46 mM; ultrasonic and warming and adjust pH to 2 with HCl and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2168 mL 11.0838 mL 22.1675 mL
5 mM 0.4434 mL 2.2168 mL 4.4335 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Calculateur de molarité

  • Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Pureté et documentation
Références

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.2168 mL 11.0838 mL 22.1675 mL 55.4189 mL
5 mM 0.4434 mL 2.2168 mL 4.4335 mL 11.0838 mL
10 mM 0.2217 mL 1.1084 mL 2.2168 mL 5.5419 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Magnesium citrate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Magnesium3344-18-1Trimagnesium dicitrateToll-like Receptor (TLR)oralsupplementation bowel preparation agentintestinal cleanserInhibitorinhibitorinhibit

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