Magnocurarine chloride
Magnocurarine chloride is a neuromuscular junction blocker that inhibits muscle contraction by functionally blocking signal transmission without directly damaging nerve or muscle tissues. In frog, mouse and rabbit models, Magnocurarine chloride exerts a dose-dependent paralytic effect, which progresses gradually from limb weakness and loss of righting reflex to respiratory depression and even cardiac arrest. Although high doses cause complete cessation of movement, Magnocurarine chloride does not affect the spinal multineuronal reflex in frogs. Magnocurarine chloride exhibits biological activity similar to that of tubocurarine (HY-125901) in various animal models.
For research use only. We do not sell to patients.
- CAS No.: 75413-87-5
- Formula: C19H24ClNO3
- Molecular Weight:349.85
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Magnocurarine chloride (5-15.63 mg/kg; i.v.; single dose) produces dose-dependent neuromuscular blockade and respiratory effects in urethane (HY-B1207)-anesthetized rabbits. A dose of 15 mg/kg induces complete muscular paralysis and respiratory arrest, with full recovery of animals occurring within 25-30 min[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:autumn-collected frogs[1]
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Dosage:0.25 mg/10g; 0.5 mg/10g; 0.75 mg/10g; 1.0 mg/10g; 1 mg/10g
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Administration:ventral lymph sac; single dose
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Result:Slowed but did not abolish the righting reaction at 0.25 mg/10g.
Abolished the righting reaction while retaining weak skin reflexes and visible respiratory movements at 0.5 mg/10g.
Stopped all movements including respiration, with paralysis persisting for 165 minutes at 0.75 mg/10g.
Caused full paralysis persisting for 330 minutes at 1.0 mg/10g.
Completely blocked gastrocnemius muscle contraction in response to sciatic nerve stimulation by 25 minutes post-injection in unligated legs at 0.75 mg/10g, while ligated (drug-free) legs retained responsiveness.
Did not depress the spinal multineuron reflex at 1 mg/10g, as the drug-free ligated leg's gastrocnemius muscle still contracted in response to sciatic nerve stimulation after full limb paralysis.
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Animal Model:Rabbit (2.0-2.5 kg; urethane-anesthetized)[1]
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Dosage:15.63 mg/kg (head drop); 5 mg/kg; 10 mg/kg; 15 mg/kg
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Administration:i.v.; single dose (over 5 seconds); i.v.; 2 mg/15 sec infusion
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Result:Produced head drop at 15.63 mg/kg (delivered as 2 mg/15 sec).
Decreased gastrocnemius muscle contraction intensity for 5-8 minutes, caused early respiratory depression followed by stimulation lasting 8-10 minutes at 5 mg/kg.
Caused more marked inhibition of muscle twitch and respiratory effects with longer duration than the 5 mg/kg dose at 10 mg/kg.
Completely abolished gastrocnemius muscle contraction within 1 minute, ceased respiratory movements, with recovery of muscle response and spontaneous respiration starting at 7-8 minutes post-injection, and full recovery within 25-30 minutes at 15 mg/kg.
Chemical Information
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CAS No. 75413-87-5
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Molecular Weight 349.85
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Formula C19H24ClNO3
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SMILES
COC(C=C(CC[N+]1(C)C)C([C@H]1CC2=CC=C(C=C2)O)=C3)=C3O.[Cl-]
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Magnocurarine chloride Related Classifications
HY-N6609B Related Classifications
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