2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. Magnocurarine chloride

Magnocurarine chloride is a neuromuscular junction blocker that inhibits muscle contraction by functionally blocking signal transmission without directly damaging nerve or muscle tissues. In frog, mouse and rabbit models, Magnocurarine chloride exerts a dose-dependent paralytic effect, which progresses gradually from limb weakness and loss of righting reflex to respiratory depression and even cardiac arrest. Although high doses cause complete cessation of movement, Magnocurarine chloride does not affect the spinal multineuronal reflex in frogs. Magnocurarine chloride exhibits biological activity similar to that of tubocurarine (HY-125901) in various animal models.

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Magnocurarine chloride

Magnocurarine chloride Chemical Structure

CAS No. : 75413-87-5

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Magnocurarine chloride Related Antibodies

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Description

Magnocurarine chloride is a neuromuscular junction blocker that inhibits muscle contraction by functionally blocking signal transmission without directly damaging nerve or muscle tissues. In frog, mouse and rabbit models, Magnocurarine chloride exerts a dose-dependent paralytic effect, which progresses gradually from limb weakness and loss of righting reflex to respiratory depression and even cardiac arrest. Although high doses cause complete cessation of movement, Magnocurarine chloride does not affect the spinal multineuronal reflex in frogs. Magnocurarine chloride exhibits biological activity similar to that of tubocurarine (HY-125901) in various animal models[1][2].

In Vivo

Magnocurarine chloride (0.25-1 mg/10g; injected via the ventral lymph sac; single dose) produces dose-dependent neuromuscular paralysis in frogs. A complete respiratory paralysis (lasting 165 min) occurs at the dose of 0.75 mg/10g, while the dose of 1 mg/10g has no effect on the spinal multineuronal reflex[1].
Magnocurarine chloride (5-15.63 mg/kg; i.v.; single dose) produces dose-dependent neuromuscular blockade and respiratory effects in urethane (HY-B1207)-anesthetized rabbits. A dose of 15 mg/kg induces complete muscular paralysis and respiratory arrest, with full recovery of animals occurring within 25-30 min[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: autumn-collected frogs[1]
Dosage: 0.25 mg/10g; 0.5 mg/10g; 0.75 mg/10g; 1.0 mg/10g; 1 mg/10g
Administration: ventral lymph sac; single dose
Result: Slowed but did not abolish the righting reaction at 0.25 mg/10g.
Abolished the righting reaction while retaining weak skin reflexes and visible respiratory movements at 0.5 mg/10g.
Stopped all movements including respiration, with paralysis persisting for 165 minutes at 0.75 mg/10g.
Caused full paralysis persisting for 330 minutes at 1.0 mg/10g.
Completely blocked gastrocnemius muscle contraction in response to sciatic nerve stimulation by 25 minutes post-injection in unligated legs at 0.75 mg/10g, while ligated (drug-free) legs retained responsiveness.
Did not depress the spinal multineuron reflex at 1 mg/10g, as the drug-free ligated leg's gastrocnemius muscle still contracted in response to sciatic nerve stimulation after full limb paralysis.
Animal Model: Rabbit (2.0-2.5 kg; urethane-anesthetized)[1]
Dosage: 15.63 mg/kg (head drop); 5 mg/kg; 10 mg/kg; 15 mg/kg
Administration: i.v.; single dose (over 5 seconds); i.v.; 2 mg/15 sec infusion
Result: Produced head drop at 15.63 mg/kg (delivered as 2 mg/15 sec).
Decreased gastrocnemius muscle contraction intensity for 5-8 minutes, caused early respiratory depression followed by stimulation lasting 8-10 minutes at 5 mg/kg.
Caused more marked inhibition of muscle twitch and respiratory effects with longer duration than the 5 mg/kg dose at 10 mg/kg.
Completely abolished gastrocnemius muscle contraction within 1 minute, ceased respiratory movements, with recovery of muscle response and spontaneous respiration starting at 7-8 minutes post-injection, and full recovery within 25-30 minutes at 15 mg/kg.
Molecular Weight

349.85

Formula

C19H24ClNO3
CAS No.
SMILES

COC(C=C(CC[N+]1(C)C)C([C@H]1CC2=CC=C(C=C2)O)=C3)=C3O.[Cl-]
Structure Classification
Initial Source
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Keywords:

Magnocurarine75413-87-5nAChRNicotinic acetylcholine receptorsurethane-anesthetized rabbitsrabbitsnerve stimulationmicerespiratory arrestneuromuscular junctionmuscle contractionrabbit gastrocnemius musclespinal multineuron reflexesfrogsInhibitorinhibitorinhibit

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