75413-87-5
Chemical Structure
Magnocurarine chloride
- CAS No.: 75413-87-5
- Formula:C19H24ClNO3
- Molecular Weight:349.85
InChIKey: VPFXIJWKEYUDJZ-UNTBIKODSA-N
SMILES: COC(C=C(CC[N+]1(C)C)C([C@H]1CC2=CC=C(C=C2)O)=C3)=C3O.[Cl-]
Biological Activity: Magnocurarine chloride is a neuromuscular junction blocker that inhibits muscle contraction by functionally blocking signal transmission without directly damaging nerve or muscle tissues. In frog, mouse and rabbit models, Magnocurarine chloride exerts a dose-dependent paralytic effect, which progresses gradually from limb weakness and loss of righting reflex to respiratory depression and even cardiac arrest. Although high doses cause complete cessation of movement, Magnocurarine chloride does not affect the spinal multineuronal reflex in frogs. Magnocurarine chloride exhibits biological activity similar to that of tubocurarine (HY-125901) in various animal models[1][2].
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Magnocurarine chloride | Magnocurarine chloride is a neuromuscular junction blocker that inhibits muscle contraction by functionally blocking signal transmission without directly damaging nerve or muscle tissues. In frog, mouse and rabbit models, Magnocurarine chloride exerts a dose-dependent paralytic effect, which progresses gradually from limb weakness and loss of righting reflex to respiratory depression and even cardiac arrest. Although high doses cause complete cessation of movement, Magnocurarine chloride does not affect the spinal multineuronal reflex in frogs. Magnocurarine chloride exhibits biological activity similar to that of tubocurarine (HY-125901) in various animal models. | |||||||||||||||||||||
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- [1]. OGIU K, et al. Curare-like action of magnocurarine, isolated from Magnolia obovata[J]. The Japanese Journal of Pharmacology, 1953, 2(2): 89-96.
- [2]. Kimura I, et al. Neuromuscular blocking action of alkaloids from a Japanese crude drug “Shin-I”(Flos Magnoliae) in frog skeletal muscle[J]. Planta medica, 1983, 48(05): 43-47.
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