Magnocurarine
Magnocurarine is a neuromuscular junction blocker that inhibits muscle contraction by functionally blocking signal transmission without directly damaging nerve or muscle tissues. In frog, mouse and rabbit models, Magnocurarine exerts a dose-dependent paralytic effect, which progresses gradually from limb weakness and loss of righting reflex to respiratory depression and even cardiac arrest. Although high doses cause complete cessation of movement, Magnocurarine does not affect the spinal multineuronal reflex in frogs. Magnocurarine exhibits biological activity similar to that of tubocurarine (HY-125901) in various animal models.
For research use only. We do not sell to patients.
- CAS No.: 6801-40-7
- Formula: C19H24NO3
- Molecular Weight:314.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Magnocurarine (5-15.63 mg/kg; i.v.; single dose) produces dose-dependent neuromuscular blockade and respiratory effects in urethane (HY-B1207)-anesthetized rabbits. A dose of 15 mg/kg induces complete muscular paralysis and respiratory arrest, with full recovery of animals occurring within 25-30 min[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 6801-40-7
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Molecular Weight 314.40
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Formula C19H24NO3
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SMILES
OC1=CC=C(C[C@@H]2C3=CC(O)=C(C=C3CC[N+]2(C)C)OC)C=C1
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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