Magnocurarine 

Magnocurarine is a neuromuscular junction blocker that inhibits muscle contraction by functionally blocking signal transmission without directly damaging nerve or muscle tissues. In frog, mouse and rabbit models, Magnocurarine exerts a dose-dependent paralytic effect, which progresses gradually from limb weakness and loss of righting reflex to respiratory depression and even cardiac arrest. Although high doses cause complete cessation of movement, Magnocurarine does not affect the spinal multineuronal reflex in frogs. Magnocurarine exhibits biological activity similar to that of tubocurarine (HY-125901) in various animal models^[1][2].

Magnocurarine (0.25-1 mg/10g; injected via the ventral lymph sac; single dose) produces dose-dependent neuromuscular paralysis in frogs. A complete respiratory paralysis (lasting 165 min) occurs at the dose of 0.75 mg/10g, while the dose of 1 mg/10g has no effect on the spinal multineuronal reflex^[1].
Magnocurarine (5-15.63 mg/kg; i.v.; single dose) produces dose-dependent neuromuscular blockade and respiratory effects in urethane (HY-B1207)-anesthetized rabbits. A dose of 15 mg/kg induces complete muscular paralysis and respiratory arrest, with full recovery of animals occurring within 25-30 min^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

314.40

C₁₉H₂₄NO₃

6801-40-7

OC1=CC=C(C[C@@H]2C3=CC(O)=C(C=C3CC[N+]2(C)C)OC)C=C1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. OGIU K, et al. Curare-like action of magnocurarine, isolated from Magnolia obovata[J]. The Japanese Journal of Pharmacology, 1953, 2(2): 89-96.

  [2]. Kimura I, et al. Neuromuscular blocking action of alkaloids from a Japanese crude drug “Shin-I”(Flos Magnoliae) in frog skeletal muscle[J]. Planta medica, 1983, 48(05): 43-47.