6801-40-7
Chemical Structure
Magnocurarine
- CAS No.: 6801-40-7
- Formula:C19H24NO3
- Molecular Weight:314.40
IUPAC Name: (R)-7-hydroxy-1-(4-hydroxybenzyl)-6-methoxy-2,2-dimethyl-1,2,3,4-tetrahydroisoquinolin-2-ium
InChIKey: CLWOXNLVWMXBRD-QGZVFWFLSA-O
SMILES: OC1=CC=C(C[C@@H]2C3=CC(O)=C(C=C3CC[N+]2(C)C)OC)C=C1
Biological Activity: Magnocurarine is a neuromuscular junction blocker that inhibits muscle contraction by functionally blocking signal transmission without directly damaging nerve or muscle tissues. In frog, mouse and rabbit models, Magnocurarine exerts a dose-dependent paralytic effect, which progresses gradually from limb weakness and loss of righting reflex to respiratory depression and even cardiac arrest. Although high doses cause complete cessation of movement, Magnocurarine does not affect the spinal multineuronal reflex in frogs. Magnocurarine exhibits biological activity similar to that of tubocurarine (HY-125901) in various animal models[1][2].
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Magnocurarine | Magnocurarine is a neuromuscular junction blocker that inhibits muscle contraction by functionally blocking signal transmission without directly damaging nerve or muscle tissues. In frog, mouse and rabbit models, Magnocurarine exerts a dose-dependent paralytic effect, which progresses gradually from limb weakness and loss of righting reflex to respiratory depression and even cardiac arrest. Although high doses cause complete cessation of movement, Magnocurarine does not affect the spinal multineuronal reflex in frogs. Magnocurarine exhibits biological activity similar to that of tubocurarine (HY-125901) in various animal models. | |||||||||||||||||||||
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- [1]. OGIU K, et al. Curare-like action of magnocurarine, isolated from Magnolia obovata[J]. The Japanese Journal of Pharmacology, 1953, 2(2): 89-96.
- [2]. Kimura I, et al. Neuromuscular blocking action of alkaloids from a Japanese crude drug “Shin-I”(Flos Magnoliae) in frog skeletal muscle[J]. Planta medica, 1983, 48(05): 43-47.
Keywords
