2. Academic Validation
  3. Resveratrol promotes HSV-2 replication by increasing histone acetylation and activating NF-κB

Resveratrol promotes HSV-2 replication by increasing histone acetylation and activating NF-κB

  • Biochem Pharmacol. 2020 Jan;171:113691. doi: 10.1016/j.bcp.2019.113691.
Liqiong Ding 1,  Ping Jiang 1,  Xinfeng Xu 1,  Wanzhen Lu 1,  Chan Yang 1,  Pingzheng Zhou 2,  Shuwen Liu 3
Affiliations

Affiliations

  • 1 Guangdong Provincial Key Laboratory of New Drug Screening, Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
  • 2 Guangdong Provincial Key Laboratory of New Drug Screening, Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China. Electronic address: [email protected].
  • 3 Guangdong Provincial Key Laboratory of New Drug Screening, Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China; State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Southern Medical University, Guangzhou 510515, China. Electronic address: [email protected].
PMID: 31704236 DOI: 10.1016/j.bcp.2019.113691
Abstract

Resveratrol is a natural compound found in many plant species that has broad therapeutic benefits. Here, we investigated the effects of resveratrol on the replication of HSV-2. We found that resveratrol accelerated replication of HSV-2 and increased release of progeny virion. A time-of-addition study suggested that resveratrol worked primarily in the early stage of viral Infection. Resveratrol regulated HSV-2 Infection by increasing histone acetylation and activating NF-κB. In addition, inhibition of CDK9 activity restrained the promoting effect of resveratrol on HSV-2 Infection. Altogether, our experiments revealed the regulatory effect of resveratrol and its mechanism of action on HSV-2 replication.

Keywords

CDK9; Herpes simplex virus 2; Histone acetylation; NF-κB; Resveratrol.

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