2. Academic Validation
  3. NCAPD2 inhibits autophagy by regulating Ca2+/CAMKK2/AMPK/mTORC1 pathway and PARP-1/SIRT1 axis to promote colorectal cancer

NCAPD2 inhibits autophagy by regulating Ca2+/CAMKK2/AMPK/mTORC1 pathway and PARP-1/SIRT1 axis to promote colorectal cancer

  • Cancer Lett. 2021 Nov 1;520:26-37. doi: 10.1016/j.canlet.2021.06.029.
Zuolei Jing 1,  Xinyuan He 2,  Zhirong Jia 2,  Yunli Sa 2,  Bolin Yang 3,  Ping Liu 4
Affiliations

Affiliations

  • 1 College of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu, People's Republic of China. Electronic address: [email protected].
  • 2 College of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu, People's Republic of China.
  • 3 Department of Colorectal Surgery, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China.
  • 4 College of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu, People's Republic of China. Electronic address: [email protected].
PMID: 34229059 DOI: 10.1016/j.canlet.2021.06.029
Abstract

Non-SMC condensin I complex subunit D2 (NCAPD2) is one of the three non-SMC subunits in condensin I. Previous studies have shown that NCAPD2 plays an important role in the chromosome condensation and segregation. However, its role in the development of colorectal Cancer (CRC) and specific molecular mechanisms still need to be further studied. Here we show that NCAPD2 inhibits Autophagy and blocks autophagic flux via Ca2+/CAMKK/AMPK/mTORC1 pathway and PARP-1/SIRT1 axis. NCAPD2 acts as a tumor promoter both in vitro and in vivo. NCAPD2 knockout suppresses colorectal Cancer development in AOM/DSS induced mice model. Therefore, our findings support a role for NCAPD2 in Autophagy to promote CRC development and highlight NCAPD2 as a potential target for CRC therapy.

Keywords

Autophagy; CAMKK/AMPK pathway; Colorectal cancer; NCAPD2; PARP-1/SIRT1.

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