2. Academic Validation
  3. Health promoting benefits of pongamol: An overview

Health promoting benefits of pongamol: An overview

  • Biomed Pharmacother. 2021 Oct:142:112109. doi: 10.1016/j.biopha.2021.112109.
Shamima Jahan 1,  Md Hasan Mahmud 2,  Zidan Khan 3,  Ashraful Alam 4,  Anees Ahmed Khalil 5,  Abdur Rauf 6,  Abu Montakim Tareq 7,  Firzan Nainu 8,  Syed Mohammed Tareq 9,  Talha Bin Emran 10,  Muneeb Khan 11,  Ishaq N Khan 12,  Polrat Wilairatana 13,  Mohammad S Mubarak 14
Affiliations

Affiliations

  • 1 Department of Pharmacy, International Islamic University Chittagong, Chittagong 4318, Bangladesh. Electronic address: [email protected].
  • 2 Department of Pharmacy, International Islamic University Chittagong, Chittagong 4318, Bangladesh. Electronic address: [email protected].
  • 3 Department of Pharmacy, International Islamic University Chittagong, Chittagong 4318, Bangladesh. Electronic address: [email protected].
  • 4 Department of Pharmacy, International Islamic University Chittagong, Chittagong 4318, Bangladesh. Electronic address: [email protected].
  • 5 University Institute of Diet and Nutritional Sciences, Faculty of Allied Health Sciences, The University of Lahore, Pakistan. Electronic address: [email protected].
  • 6 Department of Chemistry, University of Swabi, Swabi, Anbar 23430, Khyber Pakhtunkhwa, Pakistan. Electronic address: [email protected].
  • 7 Department of Pharmacy, International Islamic University Chittagong, Chittagong 4318, Bangladesh. Electronic address: [email protected].
  • 8 Faculty of Pharmacy, Hasanuddin University, Tamalanrea, Makassar 90245, Indonesia. Electronic address: [email protected].
  • 9 Department of Pharmacy, International Islamic University Chittagong, Chittagong 4318, Bangladesh. Electronic address: [email protected].
  • 10 Department of Pharmacy, BGC Trust University Bangladesh, Chittagong 4381, Bangladesh. Electronic address: [email protected].
  • 11 Department of Human Nutrition and Dietetics, Riphah College of Rehabilitation and Allied Health Sciences, Riphah International University Lahore, Pakistan. Electronic address: [email protected].
  • 12 Institute of Basic Medical Sciences, Khyber Medical University, Peshawar 25100, Pakistan. Electronic address: [email protected].
  • 13 Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. Electronic address: [email protected].
  • 14 Department of Chemistry, The University of Jordan, Amman 11942, Jordan. Electronic address: [email protected].
PMID: 34470730 DOI: 10.1016/j.biopha.2021.112109
Abstract

Plant-derived chemicals are a source of novel chemotherapeutic agents. Throughout the human civilization, these novel chemicals have led to the discovery of new pharmacological active agents. Research on herbal medicine is of great importance, as most of the active agents used for treating numerous diseases are from natural sources, while Other agents are either semisynthetic or synthetic. Pongamol, a flavonoid, which is the main constituent of Pongamia pinnata, is one such active agents, which exhibits diverse pharmacological activities. Various in vivo and in vitro studies revealed that pongamol is a potentially active agent, as it exerts Anticancer, anti-inflammatory, antioxidant, antimicrobial, and anti-diabetic activities. Accordingly, the aim of the present review was to give an up-to-date overview on the chemistry, isolation, bioavailability, pharmacological activity, and health benefits of pongamol. This review focuses on the medicinal and health promoting activities of pongamol, along with possible mechanisms of action. For this purpose, this review summarizes the most recent literature pertaining to pongamol as a therapeutic agent against several diseases. In addition, the review covers information related to the toxicological assessment and safety of this phytochemical, and highlights the medicinal and folk values of this compound against various diseases and ailments.

Keywords

Anti-diabetic; Anticancer; Antimicrobial; Antioxidant; Health benefits; Mechanisms of action; Pongamol.

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