2. Cell Cycle/DNA Damage Apoptosis
  3. DNA Alkylator/Crosslinker Apoptosis
  4. Melflufen

Melflufen  (Synonyms: Melphalan flufenamide)

Art. -Nr.: HY-105019 Reinheit: 95.46%
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Melflufen (Melphalan flufenamide), a dipeptide proagent of Melphalan, is an alkylating agent. Melflufen shows antitumor activity against multiple myeloma (MM) cells and inhibits angiogenesis. Melflufen induces irreversible DNA damage and cytotoxicity in MM cells.

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Kundenspezifische Peptidsynthese

Melflufen

Melflufen Chemische Struktur

CAS. Nr. : 380449-51-4

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Based on 1 publication(s) in Google Scholar

Other Forms of Melflufen:

Melflufen Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Melflufen

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Beschreibung

Melflufen (Melphalan flufenamide), a dipeptide proagent of Melphalan, is an alkylating agent. Melflufen shows antitumor activity against multiple myeloma (MM) cells and inhibits angiogenesis. Melflufen induces irreversible DNA damage and cytotoxicity in MM cells[1][2][3].

Cellular Effect
Cell Line Type Value Description References
Lymphoma cell line IC50
0.011 μM
Compound: Melflufen
Cytotoxicity against patient-derived human lymphoma cells assessed as cell growth inhibition incubated for 72 hrs by FMCA assay
Cytotoxicity against patient-derived human lymphoma cells assessed as cell growth inhibition incubated for 72 hrs by FMCA assay
[PMID: 35665692]
In Vitro

Melflufen (Melphalan flufenamide) (0.5-10 μM; 24 hours) decreases viability of MM.1S, INA-6, RPMI-8226, MM.1R, Dox-40, ARP-1, and ANBL-6 cells in a concentration-dependent manner[1].
Melflufen induces apoptosis in MM.1S cells[1].
Melphalan also is a potent activator of exosome secretion[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Melflufen Related Antibodies

Cell Viability Assay

Cell Line: Multiple myeloma cells: MM.1S, INA-6, RPMI-8226, MM.1R, Dox-40, ARP-1, ANBL-6 cells
Concentration: 0.5, 1, 3, 5, 10 μM
Incubation Time: 24 hours
Result: A significant concentration-dependent decrease in viability of all cell lines was observed.
In Vivo

Melflufen (Melphalan flufenamide) (3 mg/kg; i.v.; twice-weekly for two weeks) shows anti-MM activity in xenograft mouse model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CB-17 SCID mice (human plasmacytoma MM.1S xenograft mouse model)[1]
Dosage: 3 mg/kg
Administration: I.v.; twice-weekly for two weeks
Result: Significantly inhibited MM tumor growth and prolonged survival of mice.
Klinische Studie
Molekulargewicht

498.42

Formel

C24H30Cl2FN3O3
CAS. Nr.
Appearance

Oil

Color

Colorless to light yellow

Versand

Room temperature in continental US; may vary elsewhere.
Speicherung
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Reinheit & Dokumentation
Verweise
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Melflufen Related Classifications

  • Molaritätsrechner

  • Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Melflufen380449-51-4Melphalan flufenamideDNA Alkylator/CrosslinkerApoptosismultiplemyelomasurvivalMM.1ScellsDNAdamageangiogenesisgrowthInhibitorinhibitorinhibit

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