Methylophiopogonanone A

Name: Methylophiopogonanone A
Brand: MedChemExpress
SKU: HY-N2437
Rating: 4.5 (1 reviews)

Art. -Nr.: HY-N2437 Reinheit: 99.65%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Methylophiopogonanone A, a major homoisoflavonoid in Ophiopogon japonicas, has both anti-oxidative and anti-inflammatory properties.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Methylophiopogonanone A Chemische Struktur

CAS. Nr. : 74805-92-8

Größe	Verfügbarkeit	Menge
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	Auf Lager	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	Auf Lager	Estimated Time of Arrival: December 31
Solid
5 mg	Auf Lager	Estimated Time of Arrival: December 31
10 mg	Auf Lager	Estimated Time of Arrival: December 31
50 mg	Angebot einholen
100 mg	Angebot einholen

or Massenanfrage

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

This product is a controlled substance and not for sale in your territory.

Kundenbewertung

Based on 1 publication(s) in Google Scholar

Other Forms of Methylophiopogonanone A:

Methylophiopogonanone A (Standard) Angebot einholen

1 Publications Citing Use of MCE Methylophiopogonanone A

•Eur J Pharmacol. 2023 Apr 5:944:175604. [Abstract]

Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biologische Aktivität
Reinheit & Dokumentation
Verweise
Kundenbewertung

Beschreibung

Methylophiopogonanone A, a major homoisoflavonoid in Ophiopogon japonicas, has both anti-oxidative and anti-inflammatory properties^[1].

In Vitro

Methylophiopogonanone A (MO-A; 10 μmol/L) significantly decreases apoptosis and cleaved caspase-3 expression, elevated the Bcl-2/Bax ratio and restored NO production. Pretreatment with Methylophiopogonanone A (MO-A) markedly increases the activation of PI3K/Akt/eNOS pathway in H9C2 cells subjected to H/R, and the protective effects of MO-A are abolished in the presence of the PI3K inhibitor wortmannin (100 nmol/L)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Methylophiopogonanone A (MO-A;10 mg/kg/d, po) for 2 weeks) protects cardiac function following myocardial I/R injury^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molekulargewicht

342.34

Formel

C₁₉H₁₈O₆

CAS. Nr.

74805-92-8

Appearance

Solid

Color

White to off-white

SMILES

O=C1[C@H](CC2=CC=C(OCO3)C3=C2)COC4=C(C)C(O)=C(C)C(O)=C14

Structure Classification

Initial Source

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (292.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9211 mL	14.6054 mL	29.2107 mL
5 mM	0.5842 mL	2.9211 mL	5.8421 mL
10 mM	0.2921 mL	1.4605 mL	2.9211 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (7.30 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Reinheit & Dokumentation

Purity: 99.65%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (248 KB) HNMR (117 KB) CNMR (135 KB) RP-HPLC (270 KB) MS (83 KB)

Handling Instructions (2659 KB)

Verweise

[1]. He F, et al. Methylophiopogonanone A suppresses ischemia/reperfusion-induced myocardial apoptosis in mice via activating PI3K/Akt/eNOS signaling pathway. Acta Pharmacol Sin. 2016 Jun;37(6):763-71. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.9211 mL	14.6054 mL	29.2107 mL	73.0268 mL
	5 mM	0.5842 mL	2.9211 mL	5.8421 mL	14.6054 mL
	10 mM	0.2921 mL	1.4605 mL	2.9211 mL	7.3027 mL
	15 mM	0.1947 mL	0.9737 mL	1.9474 mL	4.8685 mL
	20 mM	0.1461 mL	0.7303 mL	1.4605 mL	3.6513 mL
	25 mM	0.1168 mL	0.5842 mL	1.1684 mL	2.9211 mL
	30 mM	0.0974 mL	0.4868 mL	0.9737 mL	2.4342 mL
	40 mM	0.0730 mL	0.3651 mL	0.7303 mL	1.8257 mL
	50 mM	0.0584 mL	0.2921 mL	0.5842 mL	1.4605 mL
	60 mM	0.0487 mL	0.2434 mL	0.4868 mL	1.2171 mL
	80 mM	0.0365 mL	0.1826 mL	0.3651 mL	0.9128 mL
	100 mM	0.0292 mL	0.1461 mL	0.2921 mL	0.7303 mL