2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. RAR/RXR
  4. MM11253

MM11253 is a potent and selective RARγ antagonist with an IC50 of 44 nM. MM11253 has lower inhibition of RARα, RARβ and RXRα. MM11253 blocks the growth inhibitory effects of RARγ-selective agonists.

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MM11253

MM11253 構造式

CAS 番号 : 345952-44-5

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 102 在庫あり
Solution
10 mM * 1 mL in DMSO USD 102 在庫あり
Solid
5 mg $100 在庫あり
10 mg $160 在庫あり
25 mg $350 在庫あり
50 mg $550 在庫あり
100 mg $950 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 1 publication(s) in Google Scholar

Other Forms of MM11253:

MM11253 関連抗体

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RAR/RXR アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
RXRα RXRβ RXRγ

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  • 純度とドキュメンテーション

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製品説明

MM11253 is a potent and selective RARγ antagonist with an IC50 of 44 nM. MM11253 has lower inhibition of RARα, RARβ and RXRα. MM11253 blocks the growth inhibitory effects of RARγ-selective agonists[1][3].

Cellular Effect
Cell Line Type Value Description References
Sf9 IC50
0.06 μM
Compound: 15b
Inhibition of microsomal fraction of human CYP26A1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addition measured after 1 min by HPLC analysis in presence of rat P450 reductase
Inhibition of microsomal fraction of human CYP26A1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addition measured after 1 min by HPLC analysis in presence of rat P450 reductase
[PMID: 26918322]
Sf9 IC50
1.03 μM
Compound: 15b
Inhibition of microsomal fraction of human CYP26B1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addition measured after 5 mins by HPLC analysis in presence of rat P450 reductase
Inhibition of microsomal fraction of human CYP26B1 expressed in Sf9 cells using 9-cis-RA as substrate preincubated for 5 mins followed by NADPH addition measured after 5 mins by HPLC analysis in presence of rat P450 reductase
[PMID: 26918322]
体外実験

MM11253 blocks the ability of MM11254 and MM11389 to inhibit squamous cell carcinoma cell growth[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MM11253 関連抗体
分子量

462.67

分子式

C28H30O2S2
CAS 番号
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1=CC=C2C=C(C3(C4=CC=C5C(C)(C)CCC(C)(C)C5=C4)SCCS3)C=CC2=C1)O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 125 mg/mL (270.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1614 mL 10.8068 mL 21.6137 mL
5 mM 0.4323 mL 2.1614 mL 4.3227 mL
10 mM 0.2161 mL 1.0807 mL 2.1614 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

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体積 （開始）

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濃度 （終了）

C2

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体積 （終了）

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1614 mL 10.8068 mL 21.6137 mL 54.0342 mL
5 mM 0.4323 mL 2.1614 mL 4.3227 mL 10.8068 mL
10 mM 0.2161 mL 1.0807 mL 2.1614 mL 5.4034 mL
15 mM 0.1441 mL 0.7205 mL 1.4409 mL 3.6023 mL
20 mM 0.1081 mL 0.5403 mL 1.0807 mL 2.7017 mL
25 mM 0.0865 mL 0.4323 mL 0.8645 mL 2.1614 mL
30 mM 0.0720 mL 0.3602 mL 0.7205 mL 1.8011 mL
40 mM 0.0540 mL 0.2702 mL 0.5403 mL 1.3509 mL
50 mM 0.0432 mL 0.2161 mL 0.4323 mL 1.0807 mL
60 mM 0.0360 mL 0.1801 mL 0.3602 mL 0.9006 mL
80 mM 0.0270 mL 0.1351 mL 0.2702 mL 0.6754 mL
100 mM 0.0216 mL 0.1081 mL 0.2161 mL 0.5403 mL
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MM11253 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MM11253345952-44-5MM 11253MM-11253RAR/RXRRetinoic acid receptorsRetinoid X receptorsSelective RARγ antagonistInhibitorinhibitorinhibit

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製品名:
MM11253
製品番号:
HY-108530
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