2. Metabolic Enzyme/Protease
  3. HIF/HIF Prolyl-Hydroxylase
  4. myo-Inositol trispyrophosphate hexasodium

myo-Inositol trispyrophosphate hexasodium  (Synonyms: ITPP hexasodium)

製品番号: HY-141510 純度: 95.0%
COA 取扱説明書 Technical Support

myo-Inositol trispyrophosphate (ITPP) hexasodium is a salt form of inositol triphosphate (ITPP). myo-Inositol trispyrophosphate (ITPP) hexasodium is a membrane-permeant hemoglobin allosteric regulator. myo-Inositol trispyrophosphate (ITPP) hexasodium enhances the oxygen release capacity of red blood cells by reducing the affinity of hemoglobin to oxygen. myo-Inositol trispyrophosphate (ITPP) hexasodium can be used in the study of cardiovascular disease and cancer.

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myo-Inositol trispyrophosphate hexasodium

myo-Inositol trispyrophosphate hexasodium 構造式

CAS 番号 : 23103-35-7

容量 価格（税別） 在庫状況 数量
5 mg $180 在庫あり
10 mg $320 在庫あり
25 mg $680 在庫あり
50 mg $1150 在庫あり
100 mg $1980 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

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myo-Inositol trispyrophosphate hexasodium 関連抗体

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製品説明

myo-Inositol trispyrophosphate (ITPP) hexasodium is a salt form of inositol triphosphate (ITPP). myo-Inositol trispyrophosphate (ITPP) hexasodium is a membrane-permeant hemoglobin allosteric regulator. myo-Inositol trispyrophosphate (ITPP) hexasodium enhances the oxygen release capacity of red blood cells by reducing the affinity of hemoglobin to oxygen. myo-Inositol trispyrophosphate (ITPP) hexasodium can be used in the study of cardiovascular disease and cancer[1][2][3].

体外実験

Non-salt dose:
myo-Inositol trispyrophosphate (78 mM; 1 h) significantly reduces hypoxia-induced HIF-1α expression in red blood cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

myo-Inositol trispyrophosphate hexasodium 関連抗体
体内実験

Non-salt dose:
myo-Inositol trispyrophosphate (1.5 g/kg; intraperitoneal injection; twice a week for 4 weeks) has a protective effect in rat model of myocardial infarction[1].
myo-Inositol trispyrophosphate (1.5 g/kg; intravenous injection; once a week for 11 weeks) has antitumor activity in a rat model of pancreatic cancer[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (280-320 g) with myocardial infarction[1]
Dosage: 1.5 g/kg (Non-salt dose)
Administration: Intraperitoneal injection (i.p.); twice a week for 4 weeks
Result: Essentially halted the increase of LV dilation and significantly reduced impairment of LV ejection fraction, while it had no effect on sham-operated rats.
Animal Model: DSL-6A/C1 tumors treated immunocompetent male Lewis rats[2]
Dosage: 1.5 g/kg (Non-salt dose)
Administration: Intravenous injection (i.v.); once a week for 11 weeks
Result: Significantly extended the survival time of rats.
Basically did not cause liver metastasis and primary tumor growth was restricted to 2 cm3.
Restored the pO2 pressure in tumors reducing hypoxia-inducible and proangiogenic factors.
分子量

737.88

分子式

C6H6Na6O21P6
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=P1(O[C@]2([H])[C@@]3([H])[C@@](OP(OP(O3)(O[Na])=O)(O[Na])=O)([H])[C@]4([H])[C@@](OP(OP(O4)(O[Na])=O)(O[Na])=O)([H])[C@@]2([H])OP(O1)(O[Na])=O)O[Na]
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
溶剤 & 溶解度
体外: 

H2O : 25 mg/mL (33.88 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3552 mL 6.7762 mL 13.5523 mL
5 mM 0.2710 mL 1.3552 mL 2.7105 mL
10 mM 0.1355 mL 0.6776 mL 1.3552 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: ≥95.0%

COA (271 KB) HNMR (293 KB) CNMR (192 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.3552 mL 6.7762 mL 13.5523 mL 33.8808 mL
5 mM 0.2710 mL 1.3552 mL 2.7105 mL 6.7762 mL
10 mM 0.1355 mL 0.6776 mL 1.3552 mL 3.3881 mL
15 mM 0.0903 mL 0.4517 mL 0.9035 mL 2.2587 mL
20 mM 0.0678 mL 0.3388 mL 0.6776 mL 1.6940 mL
25 mM 0.0542 mL 0.2710 mL 0.5421 mL 1.3552 mL
30 mM 0.0452 mL 0.2259 mL 0.4517 mL 1.1294 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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myo-Inositol trispyrophosphate hexasodium Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

myo-Inositol trispyrophosphate hexasodium23103-35-7ITPP hexasodiumHIF/HIF Prolyl-HydroxylaseHypoxia-inducible factorsHIFsHIF-PHred blood cellsmyocardial infarction modelpancreatic cancer modelInhibitorinhibitorinhibit

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製品名:
myo-Inositol trispyrophosphate hexasodium
製品番号:
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