2. Metabolic Enzyme/Protease
  3. Elastase
  4. Neutrophil elastase inhibitor 5

Neutrophil elastase inhibitor 5 (compound 29) is a dual inhibitor of HNE (human neutrophil elastase) and proteinase 3 (PR3) with IC50 values of 4.91 μM and 20.69 μM, respectively. Neutrophil elastase inhibitor 5 can be used in the study of neutrophil inflammatory diseases.

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Neutrophil elastase inhibitor 5

Neutrophil elastase inhibitor 5 화학구조

CAS No. : 3020696-44-7

사이즈 가격 재고 수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO 해외재고보유
Solid
5 mg 해외재고보유
10 mg 해외재고보유
25 mg 해외재고보유
50 mg 해외재고보유
100 mg 해외재고보유
200 mg   견적 받기  
500 mg   견적 받기  

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제품 설명

Neutrophil elastase inhibitor 5 (compound 29) is a dual inhibitor of HNE (human neutrophil elastase) and proteinase 3 (PR3) with IC50 values of 4.91 μM and 20.69 μM, respectively. Neutrophil elastase inhibitor 5 can be used in the study of neutrophil inflammatory diseases[1].

IC50 & Target

IC50: 4.91 μM (HNE); 20.69 μM (PR3)[1].
Cellular Effect
Cell Line Type Value Description References
Neutrophil IC50
0.9 μM
Compound: 29
Inhibition of O2 generation in fMLP/CB-induced human neutrophils by cell based assay
Inhibition of O2 generation in fMLP/CB-induced human neutrophils by cell based assay
[PMID: 37939864]
Neutrophil IC50
1.86 μM
Compound: 29
Inhibition of elastase release in fMLP/CB-induced human neutrophils by cell based assay
Inhibition of elastase release in fMLP/CB-induced human neutrophils by cell based assay
[PMID: 37939864]
분자량

426.42

화학식

C24H18N4O4
CAS No.
Appearance

Solid

Color

Orange to red

SMILES

OC([C@H](C1=CC=CC=C1)NC(C2=NC=CC=C2/N=N/C3=C(C=CC=C4)C4=CC=C3O)=O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

DMSO : 12.5 mg/mL (29.31 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3451 mL 11.7255 mL 23.4511 mL
5 mM 0.4690 mL 2.3451 mL 4.6902 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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순도&문서
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3451 mL 11.7255 mL 23.4511 mL 58.6276 mL
5 mM 0.4690 mL 2.3451 mL 4.6902 mL 11.7255 mL
10 mM 0.2345 mL 1.1726 mL 2.3451 mL 5.8628 mL
15 mM 0.1563 mL 0.7817 mL 1.5634 mL 3.9085 mL
20 mM 0.1173 mL 0.5863 mL 1.1726 mL 2.9314 mL
25 mM 0.0938 mL 0.4690 mL 0.9380 mL 2.3451 mL
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Neutrophil elastase inhibitor 5 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Neutrophil elastase inhibitor 53020696-44-7Neutrophil elastase inhibitor5Neutrophil elastase inhibitor-5ElastaseneutrophilinflammatoryInhibitorinhibitorinhibit

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상품명:
Neutrophil elastase inhibitor 5
Cat. No.:
HY-155414
수량:
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