2. Metabolic Enzyme/Protease
  3. Elastase
  4. Neutrophil elastase inhibitor 5

Neutrophil elastase inhibitor 5 (compound 29) is a dual inhibitor of HNE (human neutrophil elastase) and proteinase 3 (PR3) with IC50 values of 4.91 μM and 20.69 μM, respectively. Neutrophil elastase inhibitor 5 can be used in the study of neutrophil inflammatory diseases.

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Neutrophil elastase inhibitor 5

Neutrophil elastase inhibitor 5 Chemical Structure

CAS No. : 3020696-44-7

Size Prix Stock Quantité
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in DMSO En stock
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Neutrophil elastase inhibitor 5 Related Antibodies

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Description

Neutrophil elastase inhibitor 5 (compound 29) is a dual inhibitor of HNE (human neutrophil elastase) and proteinase 3 (PR3) with IC50 values of 4.91 μM and 20.69 μM, respectively. Neutrophil elastase inhibitor 5 can be used in the study of neutrophil inflammatory diseases[1].

IC50 & Target

IC50: 4.91 μM (HNE); 20.69 μM (PR3)[1].
Cellular Effect
Cell Line Type Value Description References
Neutrophil IC50
0.9 μM
Compound: 29
Inhibition of O2 generation in fMLP/CB-induced human neutrophils by cell based assay
Inhibition of O2 generation in fMLP/CB-induced human neutrophils by cell based assay
[PMID: 37939864]
Neutrophil IC50
1.86 μM
Compound: 29
Inhibition of elastase release in fMLP/CB-induced human neutrophils by cell based assay
Inhibition of elastase release in fMLP/CB-induced human neutrophils by cell based assay
[PMID: 37939864]
Masse moléculaire

426.42

Formule

C24H18N4O4
CAS No.
Appearance

Solid

Color

Orange to red

SMILES

OC([C@H](C1=CC=CC=C1)NC(C2=NC=CC=C2/N=N/C3=C(C=CC=C4)C4=CC=C3O)=O)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvant et solubilité
In Vitro: 

DMSO : 12.5 mg/mL (29.31 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3451 mL 11.7255 mL 23.4511 mL
5 mM 0.4690 mL 2.3451 mL 4.6902 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Pureté et documentation
Références

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3451 mL 11.7255 mL 23.4511 mL 58.6276 mL
5 mM 0.4690 mL 2.3451 mL 4.6902 mL 11.7255 mL
10 mM 0.2345 mL 1.1726 mL 2.3451 mL 5.8628 mL
15 mM 0.1563 mL 0.7817 mL 1.5634 mL 3.9085 mL
20 mM 0.1173 mL 0.5863 mL 1.1726 mL 2.9314 mL
25 mM 0.0938 mL 0.4690 mL 0.9380 mL 2.3451 mL
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Neutrophil elastase inhibitor 5 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Neutrophil elastase inhibitor 53020696-44-7Neutrophil elastase inhibitor5Neutrophil elastase inhibitor-5ElastaseneutrophilinflammatoryInhibitorinhibitorinhibit

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