2. Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. Nuclear Hormone Receptor 4A/NR4A RAR/RXR
  4. Nurr1/RXR agonist 1

Nurr1/RXR dual agonist 1 is a dual activator of Nurr1 (EC50 = 2.6 µM) and RXR with Ks of 0.6 and 1.1 µM, respectively. Nurr1/RXR dual agonist 1 exclusively activates the heterodimer response element DR5 by selectively destabilizing the Nurr1 homodimer and stabilizing the Nurr1:RXR heterodimer. Nurr1/RXR dual agonist 1 enhances expression of a specific subset of neuroprotective Nurr1 target genes while avoiding induction of genes associated with potential off-target effects in neuronal cells. Nurr1/RXR dual agonist 1 can be used for neurodegenerative diseases research.

For research use only. We do not sell to patients.

Nurr1/RXR agonist 1

Nurr1/RXR agonist 1 Chemical Structure

CAS No. : 2231746-53-3

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Nurr1/RXR agonist 1 Related Antibodies

Top Publications Citing Use of Products

View All Nuclear Hormone Receptor 4A/NR4A Isoform Specific Products:

View All Isoforms
Nur77/NR4A1 Nurr1/NR4A2

View All RAR/RXR Isoform Specific Products:

View All Isoforms
RXRα RXRβ RXRγ

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Nurr1/RXR dual agonist 1 is a dual activator of Nurr1 (EC50 = 2.6 µM) and RXR with K[1]s of 0.6 and 1.1 µM, respectively. Nurr1/RXR dual agonist 1 exclusively activates the heterodimer response element DR5 by selectively destabilizing the Nurr1 homodimer and stabilizing the Nurr1:RXR heterodimer. Nurr1/RXR dual agonist 1 enhances expression of a specific subset of neuroprotective Nurr1 target genes while avoiding induction of genes associated with potential off-target effects in neuronal cells. Nurr1/RXR dual agonist 1 can be used for neurodegenerative diseases research[1].

IC50 & Target[1]

Nurr1/NR4A2

 

In Vitro

Nurr1/RXR agonist 1 (compound 2) (15 h) induces a considerable 3.3-fold activation of Nurr1, with both Nurr1 and RXR involved[1].
Nurr1/RXR dual agonist 1 (30 μM) diminishes Nurr1 homodimer formation while leaving the Nurr1:RXR heterodimer intact[1].
Nurr1/RXR agonist 1 (0.3-30 μM) enhances DR5-dependent transcription but does not activate NBRE or NurRE[1].
Nurr1/RXR agonist 1 (0.3-30 μM, 24 h) exhibits no toxic effect in HEK293T cells[1].
Nurr1/RXR agonist 1 (10 μM, 21 h) achieves differential modulation or functional selectivity in activating downstream gene expression programs in rat dopaminergic neurons[1].
Nurr1/RXR agonist 1 induces genes that have a higher empirical probability of containing DR5 elements in their promoter regions[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nurr1/RXR agonist 1 Related Antibodies

Real Time qPCR[1]

Cell Line: rat dopaminergic neurons
Concentration: 10 μM
Incubation Time: 21 h
Result: Induced the expression of tyrosine hydroxylase (TH), fibronectin leucine rich transmembrane protein 2 (FLRT2), brain-derived neurotrophic factor (BDNF) and collapsin response mediator protein 4 (CRMP4; Dpysl3 in rat).
Did not induced X-linked inhibitor of apoptosis protein (XIAP), sestrin 3 (SESN3), cyclin D2 (CCND2), baculoviral inhibitor of apoptosis repeat-containing 5 (BIRC5), and superoxide dismutase 2 (SOD2).
Molecular Weight

319.35

Formula

C18H19F2NO2
CAS No.
SMILES

O=C(O)CC1=CC=C(N2C(C)=C(C)C3=C2CCC(F)(F)C3)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Nurr1/RXR agonist 1 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nurr1/RXR agonist 12231746-53-3Nuclear Hormone Receptor 4A/NR4ARAR/RXRNuclear Hormone Receptor 4ANerve Growth Factor IB-like ReceptorRetinoic acid receptorsRetinoid X receptorsNurr1RXRNurr1:RXR heterodimerneurodegenerative diseasesDR5Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Nurr1/RXR agonist 1
Cat. No.:
HY-180576
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.