2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Octanoylcarnitine

Octanoylcarnitine is an orally active medium-chain acylcarnitine transport intermediate in fatty acid β-oxidation. Octanoylcarnitine is converted to octanoyl-CoA by carnitine acetyltransferase (CrAT), which then generates energy via β-oxidation in mitochondria of the heart and skeletal muscle. Octanoylcarnitine enhances grip strength and treadmill endurance, alleviates lactic acidosis, distributes in muscle and heart tissues, increases free carnitine levels, and mitigates mitochondrial stress. Octanoylcarnitine is associated with long-chain fatty acid metabolism, shows a positive correlation with subcutaneous fat area in patients with metastatic pancreatic ductal adenocarcinoma, and is closely related to central retinal artery occlusion (CRAO).

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Octanoylcarnitine

Octanoylcarnitine Chemische Struktur

CAS. Nr. : 3671-77-0

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Octanoylcarnitine Related Antibodies

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Beschreibung

Octanoylcarnitine is an orally active medium-chain acylcarnitine transport intermediate in fatty acid β-oxidation. Octanoylcarnitine is converted to octanoyl-CoA by carnitine acetyltransferase (CrAT), which then generates energy via β-oxidation in mitochondria of the heart and skeletal muscle. Octanoylcarnitine enhances grip strength and treadmill endurance, alleviates lactic acidosis, distributes in muscle and heart tissues, increases free carnitine levels, and mitigates mitochondrial stress. Octanoylcarnitine is associated with long-chain fatty acid metabolism, shows a positive correlation with subcutaneous fat area in patients with metastatic pancreatic ductal adenocarcinoma, and is closely related to central retinal artery occlusion (CRAO)[1][2][3].

In Vitro

Octanoylcarnitine (50 μM) maintains robust respiration to generate energy in isolated wild-type mouse skeletal muscle mitochondria[1].
Octanoylcarnitine (25 μM; 1 min) can be converted to octanoyl-CoA by recombinant human CrAT and CPT2 in vitro, exhibiting enzymatic activity[1].
Octanoylcarnitine (50 μM; 1 h) is efficiently converted to octanoyl-CoA by homogenates of wild-type mouse skeletal muscle and heart after incubation at 37℃[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Octanoylcarnitine Related Antibodies
In Vivo

Octanoylcarnitine (0.5 mg/g or 3% w/w; single intragastric administration or ad libitum intake for 10 days) improves exercise capacity, alleviates post-exercise lactic acidosis, and increases short-chain acylcarnitine levels in tissues and serum of LCAD-KO mice[1].
Octanoylcarnitine (0.5 mg/g; i.g.; single administration) significantly improves treadmill exercise capacity and grip strength in muscle-specific CPT2-deficient mice[1].
Octanoylcarnitine (0.5 mg/g; i.g.; single administration) is rapidly metabolized to CO2 in healthy mice, and the metabolite is detectable in exhaled breath within 10 min[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Long-Chain Acyl-CoA Dehydrogenase Knockout (LCAD-KO) (male, 12-16 weeks, LC-FAOD model)[1]
Dosage: 0.5 mg/g (exercise testing); 3% w/w (chronic feeding)
Administration: i.g.; single dose, 20 minutes prior to exercise testing; i.g.; mixed into powdered diet, ad libitum for 10 days
Result: Significantly increased treadmill running distance compared to vehicle control.
Significantly reduced post-run blood lactate levels compared to vehicle control.
Did not alter serum levels of diagnostic long-chain acylcarnitine C14:1-carnitine.
Increased serum levels of downstream short-chain acylcarnitines (C8, C6, C4, C2, free carnitine) to normal or above-normal levels.
Significantly increased free carnitine levels in liver, heart, and muscle.
Significantly increased octanoylcarnitine levels in liver and muscle.
Animal Model: muscle-specific Carnitine Palmitoyltransferase 2 Knockout (CPT2ᵐᴷᴼ) (male, LC-FAOD model)[1]
Dosage: 0.5 mg/g
Administration: i.g.; single dose, 20 minutes prior to functional testing
Result: Significantly increased treadmill top speed compared to vehicle control.
Significantly increased grip strength compared to vehicle control.
Molekulargewicht

287.40

Formel

C15H29NO4
CAS. Nr.
SMILES

O=C([O-])CC(OC(=O)CCCCCCC)C[N+](C)(C)C
Versand

Room temperature in continental US; may vary elsewhere.
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Octanoylcarnitine Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Octanoylcarnitine3671-77-0Endogenous Metabolitecentral retinal artery occlusionLCAD-KO micemuscle-specific CPT2-deficient micecarnitine acetyltransferaseβ-oxidationmetastatic pancreatic ductal adenocarcinomaCrATlong-chain fatty acid oxidation disordersskeletal muscle mitochondriaheart mitochondriaInhibitorinhibitorinhibit

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