3671-77-0
Chemical Structure
Octanoylcarnitine
- CAS No.: 3671-77-0
- Formula:C15H29NO4
- Molecular Weight:287.40
IUPAC Name: 3-(octanoyloxy)-4-(trimethylammonio)butanoate
InChIKey: CXTATJFJDMJMIY-UHFFFAOYSA-N
SMILES: O=C([O-])CC(OC(=O)CCCCCCC)C[N+](C)(C)C
Biological Activity: Octanoylcarnitine is an orally active medium-chain acylcarnitine transport intermediate in fatty acid β-oxidation. Octanoylcarnitine is converted to octanoyl-CoA by carnitine acetyltransferase (CrAT), which then generates energy via β-oxidation in mitochondria of the heart and skeletal muscle. Octanoylcarnitine enhances grip strength and treadmill endurance, alleviates lactic acidosis, distributes in muscle and heart tissues, increases free carnitine levels, and mitigates mitochondrial stress. Octanoylcarnitine is associated with long-chain fatty acid metabolism, shows a positive correlation with subcutaneous fat area in patients with metastatic pancreatic ductal adenocarcinoma, and is closely related to central retinal artery occlusion (CRAO)[1][2][3].
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Octanoylcarnitine | Octanoylcarnitine is an orally active medium-chain acylcarnitine transport intermediate in fatty acid β-oxidation. Octanoylcarnitine is converted to octanoyl-CoA by carnitine acetyltransferase (CrAT), which then generates energy via β-oxidation in mitochondria of the heart and skeletal muscle. Octanoylcarnitine enhances grip strength and treadmill endurance, alleviates lactic acidosis, distributes in muscle and heart tissues, increases free carnitine levels, and mitigates mitochondrial stress. Octanoylcarnitine is associated with long-chain fatty acid metabolism, shows a positive correlation with subcutaneous fat area in patients with metastatic pancreatic ductal adenocarcinoma, and is closely related to central retinal artery occlusion (CRAO). | |||||||||||||||||||||
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- [1]. Solo KJ, et al. Oral octanoylcarnitine alleviates exercise intolerance in mouse models of long-chain fatty acid oxidation disorders. JCI Insight. 2025;10(22):e199443. Published 2025 Oct 16. [Content Brief]
- [2]. Gunchick V, et al. Morphomics, Survival, and Metabolites in Patients With Metastatic Pancreatic Cancer. JAMA Netw Open. 2024;7(10):e2440047. Published 2024 Oct 1. [Content Brief]
- [3]. Wang C, et al. Plasmalogens and Octanoylcarnitine Serve as Early Warnings for Central Retinal Artery Occlusion. Mol Neurobiol. 2024;61(10):8026-8037. [Content Brief]
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