Octreotide dihydrochloride (Synonyms: SMS 201-995 dihydrochloride)

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Octreotide (SMS 201-995) hydrochloride is a somatostatin receptor agonist and synthetic octapeptide endogenous somatostatin analogue. Octreotide hydrochloride can bind to the somatostatin receptors which are mainly subtypes 2, 3 and 5. Octreotide hydrochloride increases Gi activity and reduces intracellular cAMP production. Octreotide hydrochloride has antitumor activity, mediates apoptosis and may also be used in disease studies in acromegaly.

For research use only. We do not sell to patients.

CAS No. : 1607842-55-6

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Other In-stock Forms of Octreotide dihydrochloride:

Octreotide

Other Forms of Octreotide dihydrochloride:

Octreotide In-stock
Octreotide pamoate Get quote

11 Publications Citing Use of MCE Octreotide dihydrochloride

Cell Proliferation/Viability Assay

Cell Imaging/Staining

In Vivo Efficacy Study

RT-PCR

: Octreotide dihydrochloride purchased from MedChemExpress. Usage Cited in: Mol Cancer. 2024 Sep 20;23(1):205. [Abstract]; In vivo assessment of octreotide sensitivity in GH3 xenografts by injecting with or without Fto knockdown GH3 cells according to tumor volume, tumor weight and growth hormone level. Octreotide (OCT) (50 μg/kg; i.p.; once daily) inhibited the growth of FTO-knockdown cells effectively and further reduced the secretion of growth hormone.

: Octreotide dihydrochloride purchased from MedChemExpress. Usage Cited in: Basic Clin Pharmacol Toxicol. 2022 Sep;131(3):174-188. [Abstract]; Effects of 0ctreotide (10 μM; 4, 8, 24 and 48 h) on cell viability after treatments. 0ctreotide significantly inhibited 3T3-L1 cell viability after 8, 24 and 48 h but not 4 h.

: Octreotide dihydrochloride purchased from MedChemExpress. Usage Cited in: Basic Clin Pharmacol Toxicol. 2022 Sep;131(3):174-188. [Abstract]; Representative western blot brands of PI3K, Akt and p-Akt with or without Octreotide (2.5-10 μM) treatments. Octreotide suppressed the expression of PI3K and p-Akt in a dose-dependent manner but showed no effects on the total Akt expression in 3T3-L1 cells.

: Octreotide dihydrochloride purchased from MedChemExpress. Usage Cited in: Basic Clin Pharmacol Toxicol. 2022 Sep;131(3):174-188. [Abstract]; Oil Red O staining was performed to illustrate lipid droplets and to determine the lipid contents. Octreotide (2.5-10 μM) treatments significantly reduced lipid contents in 3T3-L1 cells on Day 6 and Day 12 compared with the control.

: Octreotide dihydrochloride purchased from MedChemExpress. Usage Cited in: Basic Clin Pharmacol Toxicol. 2022 Sep;131(3):174-188. [Abstract]; mRNA expression of Pparg, Cebpa, Fasn, and Fabp4 with or without Octreotide (2.5–10 μM; 12 d) treatments. Octreotide suppressed mRNA levels of Pparg, Cebpa, Fasn, and Fabp4 in 3T3-L1 preadipocytes in a dose-dependent manner.

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Description

In Vitro

Octreotide hydrochloride (10^‑8mM, 6 hours) induces phosphorylated‑glycogen synthase kinase 3β (GSK3β) phosphorylation and increases glycogen synthase (GS) activity^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[3]

Cell Line:	Human hepatoblastoma HepG2 cell line
Concentration:	10^‑8mM
Incubation Time:	6 hours
Result:	Increased the protein expression levels of phosphorylated‑Akt and GSK3β by 140.8% and 12.2%, respectively and the mRNA level of GS also increased.

In Vivo

Octreotide hydrochloride (subcutaneous injection, 30 mg/kg, once, 8 weeks) can inhibit tumor growth significantly with no effect on body weight^[1].
Octreotide hydrochloride (intramuscular injection, 60 mg/kg, every 21 days, 42 days) inhibits serum insulin-like growth factor (IGF-I) without toxicity in dogs with appendicular osteosarcoma (OSA)^[2].
Octreotide hydrochloride (subcutaneous injection, 40 μg/kg, Every 12 hours, 8 days) improves hepatic glycogen synthesis in obese male Sprague‑Dawley (SD) rats^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female nude mice (nu/nu Balbc-A weighing 19-22 g)^[1]
Dosage:	30 mg/kg
Administration:	Subcutaneous injection; once; 8 weeks
Result:	Showed that the average volume of tumors treated was 25.8% of the control group and no effect on body weight.

Animal Model:	Dogs with appendicular OSA^[2]
Dosage:	60 mg/kg
Administration:	Intramuscular injection; Every 21 days; 42 days
Result:	Resulted in a 43% decrease in mean serum IGF-I compared with mean baseline concentrations.

Animal Model:	Male Sprague‑Dawley (SD) rats (3 weeks; 40-60 g)^[3]
Dosage:	40 μg/kg
Administration:	Subcutaneous injection; Every 12 hours; 8 days
Result:	Significantly improved fat deposition and reduced lipid infiltration.

Molecular Weight

1092.16

Formula

C₄₉H₆₈Cl₂N₁₀O₁₀S₂

CAS No.

1607842-55-6

Sequence

{d-Phe}-cyclo(Cys-Phe-{d-Trp}-Lys-Thr-Cys-{Threoninol}) (Disulfide bridge: Cys2-Cys7)

Sequence Shortening

{d-Phe}-cyclo(CF{d-Trp}-KTC)-{Threoninol} (Disulfide bridge: Cys2-Cys7)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Octreotide pamoate, OncoLAR, OP-LAR

[2]. Chand Khanna，et al. A randomized controlled trial of octreotide pamoate long-acting release and carboplatin versus carboplatin alone in dogs with naturally occurring osteosarcoma: evaluation of insulin-like growth factor suppression and chemotherapy. Clin Cancer Res. 2002 Jul;8(7):2406-12. [Content Brief]

[3]. Xiao-Xia Wang,et al. Effects of octreotide on hepatic glycogenesis in rats with high fat diet‑induced obesity. Mol Med Rep. 2017 Jul;16(1):109-118. [Content Brief]

Octreotide dihydrochloride Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Octreotide1607842-55-6SMS 201-995Somatostatin ReceptorApoptosisSSTRsSSTRSomatostatin receptor agonistAcromegalyCancerInhibitorinhibitorinhibit

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