1. GPCR/G Protein
    Neuronal Signaling
    Apoptosis
  2. Somatostatin Receptor
    Apoptosis
  3. Octreotide pamoate

Octreotide pamoate (Synonyms: SMS 201-995 pamoate)

Cat. No.: HY-P0036B
Handling Instructions

Octreotide (SMS 201-995) pamoate is a somatostatin receptor agonist and synthetic octapeptide endogenous somatostatin analogue. Octreotide pamoate can bind to the somatostatin receptors which are mainly subtypes 2, 3 and 5. Octreotide pamoate increases Gi activity and reduces intracellular cAMP production. Octreotide pamoate has antitumor activity, mediates apoptosis and may also be used in disease studies in acromegaly.

For research use only. We do not sell to patients.

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Octreotide pamoate Chemical Structure

Octreotide pamoate Chemical Structure

CAS No. : 135467-16-2

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Description

Octreotide (SMS 201-995) pamoate is a somatostatin receptor agonist and synthetic octapeptide endogenous somatostatin analogue. Octreotide pamoate can bind to the somatostatin receptors which are mainly subtypes 2, 3 and 5. Octreotide pamoate increases Gi activity and reduces intracellular cAMP production. Octreotide pamoate has antitumor activity, mediates apoptosis and may also be used in disease studies in acromegaly[1][2].

In Vitro

Octreotide pamoate (10‑8mM, 6 hours) induces phosphorylated‑glycogen synthase kinase 3β (GSK3β) phosphorylation and increases glycogen synthase (GS) activity[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[3]

Cell Line: Human hepatoblastoma HepG2 cell line
Concentration: 10‑8mM
Incubation Time: 6 hours
Result: Increased the protein expression levels of phosphorylated‑Akt and GSK3β by 140.8% and 12.2%, respectively and the mRNA level of GS also increased.
In Vivo

Octreotide pamoate (subcutaneous injection, 30 mg/kg, once) can inhibit tumor growth significantly with no effect on body weight[1].
Octreotide pamoate (intramuscular injection, 60 mg/kg, every 21 days, 42 days) inhibits serum insulin-like growth factor (IGF-I) without toxicity in dogs with appendicular osteosarcoma (OSA)[2].
Octreotide pamoate (subcutaneous injection, 40 μg/kg, Every 12 hours, 8 days) improves hepatic glycogen synthesis in obese male Sprague‑Dawley (SD) rats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female nude mice (nu/nu Balbc-A weighing 19-22 g)[1]
Dosage: 30 mg/kg
Administration: Subcutaneous injection; once
Result: Showed that the average volume of tumors treated was 25.8% of the control group and no effect on body weight.
Animal Model: Dogs with appendicular OSA[2]
Dosage: 60 mg/kg
Administration: Intramuscular injection; every 21 days; 42 days
Result: Resulted in a 43% decrease in mean serum IGF-I compared with mean baseline concentrations.
Animal Model: Male Sprague‑Dawley (SD) rats (3 weeks; 40-60 g)[3]
Dosage: 40 μg/kg
Administration: Subcutaneous injection; every 12 hours; 8 days
Result: Significantly improved fat deposition and reduced lipid infiltration.
Formula

C49H66N10O10S2.xC23H16O6

CAS No.
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Octreotide pamoate
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