Cat. No.: HY-P0036B

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Octreotide pamoate

Name: Octreotide pamoate
Brand: MedChemExpress
SKU: HY-P0036B
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(Synonyms: SMS 201-995 pamoate)

11 Cited Publications

Customer Review

Based on 11 publication(s) in Google Scholar

Octreotide (SMS 201-995) pamoate is a somatostatin receptor agonist and synthetic octapeptide endogenous somatostatin analogue. Octreotide pamoate can bind to the somatostatin receptors which are mainly subtypes 2, 3 and 5. Octreotide pamoate increases Gi activity and reduces intracellular cAMP production. Octreotide pamoate has antitumor activity, mediates apoptosis and may also be used in disease studies in acromegaly.

For research use only. We do not sell to patients.

CAS No.: 135467-16-2
Formula: C₄₉H₆₆N₁₀O₁₀S₂.xC₂₃H₁₆O₆

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Octreotide pamoate Chemical Structure

CAS No.: 135467-16-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (11)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

SSTR2

SSTR3

SSTR5

All Somatostatin Receptor Isoforms :

In Vitro

Octreotide pamoate (10⁸mM, 6 hours) induces phosphorylated glycogen synthase kinase 3β (GSK3β) phosphorylation and increases glycogen synthase (GS) activity^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[3]

Cell Line:

Human hepatoblastoma HepG2 cell line
Concentration:

10^‑8mM
Incubation Time:

6 hours
Result:

Increased the protein expression levels of phosphorylated‑Akt and GSK3β by 140.8% and 12.2%, respectively and the mRNA level of GS also increased.

In Vivo

Octreotide pamoate (subcutaneous injection, 30 mg/kg, once) can inhibit tumor growth significantly with no effect on body weight^[1].
Octreotide pamoate (intramuscular injection, 60 mg/kg, every 21 days, 42 days) inhibits serum insulin-like growth factor (IGF-I) without toxicity in dogs with appendicular osteosarcoma (OSA)^[2].
Octreotide pamoate (subcutaneous injection, 40 μg/kg, Every 12 hours, 8 days) improves hepatic glycogen synthesis in obese male Sprague Dawley (SD) rats^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Female nude mice (nu/nu Balbc-A weighing 19-22 g)^[1]
Dosage:

30 mg/kg
Administration:

Subcutaneous injection; once
Result:

Showed that the average volume of tumors treated was 25.8% of the control group and no effect on body weight.

Animal Model:

Dogs with appendicular OSA^[2]
Dosage:

60 mg/kg
Administration:

Intramuscular injection; every 21 days; 42 days
Result:

Resulted in a 43% decrease in mean serum IGF-I compared with mean baseline concentrations.

Animal Model:

Male Sprague‑Dawley (SD) rats (3 weeks; 40-60 g)^[3]
Dosage:

40 μg/kg
Administration:

Subcutaneous injection; every 12 hours; 8 days
Result:

Significantly improved fat deposition and reduced lipid infiltration.

Chemical Information

CAS No. 135467-16-2
Formula C₄₉H₆₆N₁₀O₁₀S₂.xC₂₃H₁₆O₆
Synonyms

SMS 201-995 pamoate
Sequence

{d-Phe}-Cys-Phe-{d-Trp}-Lys-Thr-Cys-{Threoninol} (Disulfide bridge: Cys2-Cys7)
Sequence Shortening

{d-Phe}-CF{d-Trp}-KTC-{Threoninol} (Disulfide bridge: Cys2-Cys7)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (11)

All Cell Proliferation/Viability AssayWBCell Imaging/StainingIn Vivo Efficacy StudyRT-PCR

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Journal Impact Factor

Mol Cancer

FTO-mediated DSP m6A demethylation promotes an aggressive subtype of growth hormone-secreting pituitary neuroendocrine tumors. [Abstract]

2024 Sep 20;23(1):205. PMID: 39304899

Octreotide pamoate purchased from MedChemExpress. Usage Cited in: Mol Cancer. 2024 Sep 20;23(1):205. [Abstract]

In vivo assessment of octreotide sensitivity in GH3 xenografts by injecting with or without Fto knockdown GH3 cells according to tumor volume, tumor weight and growth hormone level. Octreotide (OCT) (50 μg/kg; i.p.; once daily) inhibited the growth of FTO-knockdown cells effectively and further reduced the secretion of growth hormone.
Eur J Nucl Med Mol Imaging

Combining [177Lu]Lu-DOTA-TOC PRRT with PARP inhibitors to enhance treatment efficacy in small cell lung cancer. [Abstract]

2024 Nov;51(13):4099-4110. PMID: 39023784
J Ethnopharmacol

Revealing the temporal metabolic trajectory and potential pharmacodynamic substances of Da-Cheng-Qi Decoction in treating patients with acute pancreatitis: A serum metabolomics-based study. [Abstract]

2026 Jun 12:364:121522. PMID: 41825726
Int J Pharm

Comprehensive design and characterization of pH-gradient-loaded donkey-milk exosomes for oral octreotide delivery: A bench-to-in silico roadmap. [Abstract]

2026 Mar 12:126768. PMID: 41831704
Biomacromolecules

Investigation of Basolateral Targeting Micelles for Drug Delivery Applications in Polycystic Kidney Disease. [Abstract]

2024 May 13;25(5):2749-2761. PMID: 38652072
J Pharm Sci

Elucidating a Potential Mechanism of Permeability Enhancer Sodium N-[8-(2-hydroxybenzoyl) amino] caprylate in Rats: Evidence of Lymphatic Absorption of Cyanocobalamin Using the Mesenteric Lymph Duct Cannulated Rat. [Abstract]

2022 Dec;111(12):3417-3423. PMID: 36228756
Basic Clin Pharmacol Toxicol

Somatostatin receptor ligands suppressed proliferation and lipogenesis in 3T3-L1 preadipocytes. [Abstract]

2022 Sep;131(3):174-188. PMID: 35688794

Octreotide pamoate purchased from MedChemExpress. Usage Cited in: Basic Clin Pharmacol Toxicol. 2022 Sep;131(3):174-188. [Abstract]

Effects of 0ctreotide (10 μM; 4, 8, 24 and 48 h) on cell viability after treatments. 0ctreotide significantly inhibited 3T3-L1 cell viability after 8, 24 and 48 h but not 4 h.

Octreotide pamoate purchased from MedChemExpress. Usage Cited in: Basic Clin Pharmacol Toxicol. 2022 Sep;131(3):174-188. [Abstract]

Representative western blot brands of PI3K, Akt and p-Akt with or without Octreotide (2.5-10 μM) treatments. Octreotide suppressed the expression of PI3K and p-Akt in a dose-dependent manner but showed no effects on the total Akt expression in 3T3-L1 cells.

Octreotide pamoate purchased from MedChemExpress. Usage Cited in: Basic Clin Pharmacol Toxicol. 2022 Sep;131(3):174-188. [Abstract]

Oil Red O staining was performed to illustrate lipid droplets and to determine the lipid contents. Octreotide (2.5-10 μM) treatments significantly reduced lipid contents in 3T3-L1 cells on Day 6 and Day 12 compared with the control.

Octreotide pamoate purchased from MedChemExpress. Usage Cited in: Basic Clin Pharmacol Toxicol. 2022 Sep;131(3):174-188. [Abstract]

mRNA expression of Pparg, Cebpa, Fasn, and Fabp4 with or without Octreotide (2.5–10 μM; 12 d) treatments. Octreotide suppressed mRNA levels of Pparg, Cebpa, Fasn, and Fabp4 in 3T3-L1 preadipocytes in a dose-dependent manner.
Cell Mol Bioeng

Combining Metformin and Drug-Loaded Kidney-Targeting Micelles for Polycystic Kidney Disease. [Abstract]

2022 Dec 22;16(1):55-67. PMID: 36660586
J Pharm Biomed Anal

Analyzing proteolytic stability and metabolic hotspots of therapeutic peptides in two rodent pulmonary fluids. [Abstract]

2023 Feb 5:224:115156. PMID: 36463768
J Pharm Biomed Anal

Automated high-throughput in vitro assays to identify metabolic hotspots and protease stability of structurally diverse, pharmacologically active peptides for inhalation. [Abstract]

2022 Mar 20:211:114518. PMID: 35124452
University of Helsinki Finland

2018 Dec.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. G. Weckbecker，et al. Indirect antiproliferative effect of the somatostatin analog octreotide on MIA PaCa-2 human pancreatic carcinoma in nude mice. Yale J Biol Med. 1997 Sep-Dec;70(5-6):549-54.

[2]. Chand Khanna，et al. A randomized controlled trial of octreotide pamoate long-acting release and carboplatin versus carboplatin alone in dogs with naturally occurring osteosarcoma: evaluation of insulin-like growth factor suppression and chemotherapy. Clin Cancer Res. 2002 Jul;8(7):2406-12 [Content Brief]

[3]. Xiao-Xia Wang,et al. Effects of octreotide on hepatic glycogenesis in rats with high fat diet‑induced obesity. Mol Med Rep. 2017 Jul;16(1):109-118. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Octreotide pamoate

11 Cited Publications

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Octreotide pamoate

Publications Citing Use of MedChemExpress (MCE) Octreotide pamoate

All Somatostatin Receptor Isoforms

Biological Activity

Chemical Information

Publications (11)

Purity & Documentation

References

Calculators

Help & FAQs

Octreotide pamoate Related Classifications

HY-P0036B Related Classifications

Bioz