2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. Opakalim

Opakalim (BHV-7000) is a selective Kv7.2/7.3 potassium channels activator with an EC50 of 0.6 μM. Opakalim shows minimal GABAA receptor activation and exhibits potent anti-seizure efficacy in the maximal electroshock seizure (MES) model. Opakalim can be used for the study of seizures.

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Opakalim

Opakalim 화학구조

CAS No. : 2376397-93-0

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10 mg 해외재고보유
25 mg 해외재고보유
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100 mg 해외재고보유
200 mg   견적 받기  
500 mg   견적 받기  

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제품 설명

Opakalim (BHV-7000) is a selective Kv7.2/7.3 potassium channels activator with an EC50 of 0.6 μM. Opakalim shows minimal GABAA receptor activation and exhibits potent anti-seizure efficacy in the maximal electroshock seizure (MES) model. Opakalim can be used for the study of seizures[1][2].

IC50 & Target[2]

KV7.2

0.6 μM (EC50)

KV7.3

0.6 μM (EC50)

In Vivo

Opakalim provides protection against seizures with a brain EC50 of 0.12 μM and TD50 >20 mg/kg in the maximal electroshock seizure rats model[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
분자량

348.39

화학식

C18H22F2N4O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N#CC1=C(F)C2=C(N=C(N2C(C)(C)C)NC(CC(C)(C)C)=O)C(F)=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Store at room temperature, keep dry and cool

In solvent -80°C 1 year
-20°C 6 months
용액&용해도
In Vitro: 

DMSO : 2 mg/mL (5.74 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8703 mL 14.3517 mL 28.7035 mL
5 mM 0.5741 mL 2.8703 mL 5.7407 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8703 mL 14.3517 mL 28.7035 mL 71.7587 mL
5 mM 0.5741 mL 2.8703 mL 5.7407 mL 14.3517 mL
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Opakalim Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Opakalim2376397-93-0BHV-7000BHV7000BHV 7000Potassium ChannelKcsAKv7.2/7.3 Activatoranti-seizure efficacyInhibitorinhibitorinhibit

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상품명:
Opakalim
Cat. No.:
HY-172431
수량:
MCE Japan Authorized Agent:

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