2376397-93-0
2376397-93-0
Chemical Structure
Opakalim
Synonym(s): BHV-7000
- CAS No.: 2376397-93-0
- Formula:C18H22F2N4O
- Molecular Weight:348.39
InChIKey: VOPRSHDHZUHPBT-UHFFFAOYSA-N
SMILES: N#CC1=C(F)C2=C(N=C(N2C(C)(C)C)NC(CC(C)(C)C)=O)C(F)=C1
Biological Activity: Opakalim (BHV-7000) is a selective Kv7.2/7.3 potassium channels activator with an EC50 of 0.6 μM. Opakalim shows minimal GABAA receptor activation and exhibits potent anti-seizure efficacy in the maximal electroshock seizure (MES) model. Opakalim can be used for the study of seizures[1][2].
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Opakalim | 99.88% | Opakalim (BHV-7000) is a selective Kv7.2/7.3 potassium channels activator with an EC50 of 0.6 μM. Opakalim shows minimal GABAA receptor activation and exhibits potent anti-seizure efficacy in the maximal electroshock seizure (MES) model. Opakalim can be used for the study of seizures. | ||||||||||||||||||||
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References
- [1]. Bharat Awsare, et al. Phase 1 Study Evaluating the Safety and Tolerability of BHV-7000, a Novel, Selective Kv7.2/7.3 Potassium Channel Activator, in Healthy Adults (P8-1.007). April 9, 2024 issue.
- [2]. Picchione K, et al. Characterization of BHV-7000: A Novel Kv7. 2/7.3 Activator for the Treatment of Seizures (S29. 006)[C]//Neurology. Hagerstown, MD: Lippincott Williams & Wilkins, 2024, 102(7_supplement_1): 6119.
Keywords
