Oxalic acid diammonium monohydrate  (Synonyms: Ethanedioic acid diammonium monohydrate)

Oxalic acid (Ethanedioic acid) diammonium monohydrate is a dicarboxylic acid found in a wide variety of plants.
Oxalic acid diammonium monohydrate shows antioxidant acyivity and suppresses lipid peroxidation.
Oxalic acid diammonium monohydrate is a pathogenicity factor for sclerotinia sclerotiorum, and suppresses the oxidative burst of the host plant. Oxalic acid diammonium monohydrate exerts acaricidal activity. Oxalic acid can be used for the researches of sclerotinia disease varroatosis and inflammatory diseases^[1][2][3].

Oxalic acid (4-32 mM; 10 min) diammonium monohydrate suppresses Fe³⁺-ADP/NADPH-induced lipid peroxidation in rat liver microsomes in a concentration-dependent manner, with 32 mM reducing levels to 5.9% of control values^[1].
Oxalic acid (16 mM; 90 min) diammonium monohydrate almost completely suppresses lipid peroxidation in rat brain homogenate, reducing TBARS levels to 10% of control values^[1].
Oxalic acid (0.5-8.0 mM; 5 min) diammonium monohydrate reduces Cu²⁺/H₂O₂-induced oxidation of ascorbic acid in a cell-free in vitro system in a concentration-dependent manner, with 8.0 mM maintaining the highest ascorbate levels after 5 min of incubation^[1].
Oxalic acid (4-10 mM) diammonium monohydrate inhibits OGA-induced oxidative burst in suspension-cultured Glycine max cells with an IC₅₀ of 4 mM and achieves maximal inhibition at 6 mM^[2].
Oxalic acid (4-10 mM) diammonium monohydrate inhibits oxidative bursts induced by multiple distinct elicitors in suspension-cultured tobacco and soybean cells with IC₅₀ values of 4 to 5 mM and achieves maximal inhibition at 6 to 7 mM^[2].
Oxalic acid (10 mM) diammonium monohydrate increases OGA-induced cytosolic Ca²⁺ transients in aequorin-transformed suspension-cultured tobacco cells rather than inhibiting them^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

142.11

(NH₄)₂C₂O₄·H₂O

6009-70-7

Solid

White to off-white

O=C(C(O)=O)O.O.N.N

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

• [1]. Kayashima T, et al. Oxalic acid is available as a natural antioxidant in some systems. Biochim Biophys Acta. 2002;1573(1):1-3.  [Content Brief]

  [2]. Cessna SG, et al. Oxalic acid, a pathogenicity factor for Sclerotinia sclerotiorum, suppresses the oxidative burst of the host plant. Plant Cell. 2000;12(11):2191-2200.  [Content Brief]

  [3]. Nanetti A, Büchler R, Charrière J, et al. Oxalic acid treatments for varroa control (a review)[J]. Apiacta, 2003, 38(1): 81-7.