Oxyphencyclimine

Cat. No.: HY-B0954A: Data Sheet Handling Instructions
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Oxyphencyclimine is an orally active muscarinic receptor (mAChR) antagonist. Oxyphencyclimine is effective in reducing ulceration index and increasing pepsin activity in rat gastric ulcer model. Oxyphencyclimine can be used in studies of peptic ulcer disease and gastrointestinal spasm.

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Oxyphencyclimine 화학구조

CAS No. : 125-53-1

사이즈		재고
MOQ		Minimum order quantity
50 mg		견적 받기
100 mg		견적 받기
250 mg		견적 받기
Other size		견적 받기

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of Oxyphencyclimine:

Oxyphencyclimine hydrochloride

Other Forms of Oxyphencyclimine:

Oxyphencyclimine hydrochloride In-stock

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•Related Small Molecules:

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mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

Biological Activity
순도&문서
References
고객리뷰

제품 설명

In Vivo

Oxyphencyclimine (10 mg/kg; p.o.; single) reduces ulceration index and increases pepsin activity in rat gastric ulcer model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male or female Sprague-Dawley rats (160-170 g; Reserpine or Phenylbutazone-induced rat gastric ulcer model)^[1].
Dosage:	10 mg/kg
Administration:	Oral administration; single.
Result:	Increased pepsin activity in Reserpine-induced gastric ulcer rat from 5.9% (1 % homogenate) and 9.0% (supernatant) to 9.7% and 18.4%, respectively. Increased pepsin activity in Phenylbutazone-induced gastric ulcer rat from 13.0% (1 % homogenate) and 26.1% (supernatant) to 21.3% and 43.6%, respectively. Decreased rate of ulcers in Reserpine and Phenylbutazone-induced rat gastric ulcer model from 93% and 100 % to 38% and 60%, respectively.

분자량

344.45

화학식

C₂₀H₂₈N₂O₃

CAS No.

125-53-1

SMILES

O=C(C(C1=CC=CC=C1)(C2CCCCC2)O)OCC3=NCCCN3C

선적

Room temperature in continental US; may vary elsewhere.

보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Coppi G, et al. Experimental gastric ulcers and stomach tissue pepsin activity in the rat. J Pharm Pharmacol. 1972 Apr;24(4):332-3. [Content Brief]

[2]. Waelbroeck M, et al. Stereoselective interaction of procyclidine, hexahydro-difenidol, hexbutinol and oxyphencyclimine, and of related antagonists, with four muscarinic receptors. Eur J Pharmacol. 1992 Sep 1;227(1):33-42. [Content Brief]