125-53-1
125-53-1
Chemical Structure
Oxyphencyclimine
- CAS No.: 125-53-1
- Formula:C20H28N2O3
- Molecular Weight:344.45
IUPAC Name: (1-methyl-1,4,5,6-tetrahydropyrimidin-2-yl)methyl 2-cyclohexyl-2-hydroxy-2-phenylacetate
InChIKey: DUDKAZCAISNGQN-UHFFFAOYSA-N
SMILES: O=C(C(C1=CC=CC=C1)(C2CCCCC2)O)OCC3=NCCCN3C
Biological Activity: Oxyphencyclimine is an orally active muscarinic receptor (mAChR) antagonist. Oxyphencyclimine is effective in reducing ulceration index and increasing pepsin activity in rat gastric ulcer model. Oxyphencyclimine can be used in studies of peptic ulcer disease and gastrointestinal spasm[1][2].
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Oxyphencyclimine | Oxyphencyclimine is an orally active muscarinic receptor (mAChR) antagonist. Oxyphencyclimine is effective in reducing ulceration index and increasing pepsin activity in rat gastric ulcer model. Oxyphencyclimine can be used in studies of peptic ulcer disease and gastrointestinal spasm. | |||||||||||||||||||||
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References
- [1]. Coppi G, et al. Experimental gastric ulcers and stomach tissue pepsin activity in the rat. J Pharm Pharmacol. 1972 Apr;24(4):332-3. [Content Brief]
- [2]. Waelbroeck M, et al. Stereoselective interaction of procyclidine, hexahydro-difenidol, hexbutinol and oxyphencyclimine, and of related antagonists, with four muscarinic receptors. Eur J Pharmacol. 1992 Sep 1;227(1):33-42. [Content Brief]
Keywords
