2. Oxyphencyclimine

Oxyphencyclimine is an orally active muscarinic receptor (mAChR) antagonist. Oxyphencyclimine is effective in reducing ulceration index and increasing pepsin activity in rat gastric ulcer model. Oxyphencyclimine can be used in studies of peptic ulcer disease and gastrointestinal spasm.

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Oxyphencyclimine Chemical Structure

Oxyphencyclimine Chemical Structure

CAS No. : 125-53-1

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Oxyphencyclimine Related Antibodies

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Description

Oxyphencyclimine is an orally active muscarinic receptor (mAChR) antagonist. Oxyphencyclimine is effective in reducing ulceration index and increasing pepsin activity in rat gastric ulcer model. Oxyphencyclimine can be used in studies of peptic ulcer disease and gastrointestinal spasm[1][2].

In Vivo

Oxyphencyclimine (10 mg/kg; p.o.; single) reduces ulceration index and increases pepsin activity in rat gastric ulcer model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male or female Sprague-Dawley rats (160-170 g; Reserpine or Phenylbutazone-induced rat gastric ulcer model)[1].
Dosage: 10 mg/kg
Administration: Oral administration; single.
Result: Increased pepsin activity in Reserpine-induced gastric ulcer rat from 5.9% (1 % homogenate) and 9.0% (supernatant) to 9.7% and 18.4%, respectively.
Increased pepsin activity in Phenylbutazone-induced gastric ulcer rat from 13.0% (1 % homogenate) and 26.1% (supernatant) to 21.3% and 43.6%, respectively.
Decreased rate of ulcers in Reserpine and Phenylbutazone-induced rat gastric ulcer model from 93% and 100 % to 38% and 60%, respectively.
Molecular Weight

344.45

Formula

C20H28N2O3
CAS No.
SMILES

O=C(C(C1=CC=CC=C1)(C2CCCCC2)O)OCC3=NCCCN3C
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Oxyphencyclimine125-53-1Inhibitorinhibitorinhibit

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