2. Anti-infection
  3. RSV
  4. Palivizumab

Palivizumab  (Synonyms: MEDI 493)

Cat. No.: HY-P9944 Pureza: 99.63%
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Palivizumab (MEDI 493) is a humanized monoclonal antibody against respiratory syncytial virus (RSV). Palivizumab can bind to RSV F protein with a Kd value of 1.4 nM. Palivizumab can prevent respiratory syncytial virus infection in cotton mice.

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No. CAS : 188039-54-5

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Based on 3 publication(s) in Google Scholar

Palivizumab Recomendaciones destacadas:

Palivizumab Related Antibodies

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Descripciòn

Palivizumab (MEDI 493) is a humanized monoclonal antibody against respiratory syncytial virus (RSV). Palivizumab can bind to RSV F protein with a Kd value of 1.4 nM. Palivizumab can prevent respiratory syncytial virus infection in cotton mice[1].
Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity

Virus
IC50 & Target

RSV-F
In Vitro

Palivizumab has RSV neutralizing activity and an EC50 value of 0.95850 nM with IgG1 protein[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Palivizumab Related Antibodies
In Vivo

Palivizumab (0.625-5 mg/kg (i.m.) or 0.312-10 mg/kg (i.v.); single dose) can prevent respiratory syncytial virus infection in cotton mice[1].
Palivizumab (0.05 mg/kg; single dose; intranasally administered)can prevent RSV infection in mice[2].
Palivizumab (15 mg/kg; single dose; s.c.) can inhibit RSV induced airway neurogenic inflammation in rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: The cotton rat model of RSV infection[1].
Dosage: 0.625-5 mg/kg (i.m.) or 0.312-10 mg/kg (i.v.)
Administration: Intramuscular injection (i.m.) or intravenous injection (i.v.); single dose
Result: Reduced virus replication and did not cause RSV infection or pathological increase in both initial and secondary attacks.
Animal Model: BALB/c mice[2].
Dosage: 0.05 mg/kg
Administration: Intranasally administered; single dose
Result: Reduced the RSV load.
Animal Model: Capsaicin-induced neurogenic inflammation in the airways of rats[3].
Dosage: 15 mg/kg
Administration: Subcutaneous injection (s.c.); single dose
Result: Reduced neurogenic extravasation and neurogenic inflammation.
Ensayo clínico
Accession

A0A0X8XRK2
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Peso molecular

145.5 kDa

No. CAS
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Palivizumab]
Envío

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Immobilized Human respiratory syncytial virus (RSV) Prefusion glycoprotein F can bind Palivizumab. The EC50 for this effect is 2.043 ng/mL.
Pureza y Documentación

Purity: 99.63%

SDS (251 KB)

COA (232 KB) SDS-PAGE (67 KB) SEC-HPLC (149 KB)

Inhibitory Antibodies User Guide (603 KB)
Referencias
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Palivizumab Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Palivizumab188039-54-5MEDI 493MEDI493MEDI-493RSVRespiratory syncytial virusantibodyrespiratory tract infectionInhibitorinhibitorinhibit

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Nombre del producto:
Palivizumab
Cat. No.:
HY-P9944
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