Pantothenate kinase-IN-2

Name: Pantothenate kinase-IN-2
Brand: MedChemExpress
SKU: HY-44170
Rating: 5.0 (2 reviews)

製品番号: HY-44170 純度: 98.18%: Data Sheet SDS COA 取扱説明書
FAQs
Technical Support

Pantothenate kinase-IN-2 is a pantothenate kinase inhibitor with IC₅₀ values of 92 nM for PanK2, 70 nM for PanK1β, and 25 nM for PanK3. Pantothenate kinase-IN-2 can bind specifically to the ATP-PanK3 complex and block CoA biosynthesis. Pantothenate kinase-IN-2 can be used for the research of pank-associated neurodegeneration and type 2 diabetes.

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Pantothenate kinase-IN-2 構造式

CAS 番号 : 902614-04-4

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 121	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 121	在庫あり	Estimated Time of Arrival: December 31
Solid
1 mg	$40	在庫あり	Estimated Time of Arrival: December 31
5 mg	$110	在庫あり	Estimated Time of Arrival: December 31
10 mg	$170	在庫あり	Estimated Time of Arrival: December 31
25 mg	$400	在庫あり	Estimated Time of Arrival: December 31
50 mg		お問い合わせ
100 mg		お問い合わせ

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* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 2 publication(s) in Google Scholar

顧客検証

PANK アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

PanK1 PanK2 PanK3

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

IC₅₀ & Target^[1]

PanK3

25 nM (IC₅₀)

PanK1β

70 nM (IC₅₀)

PanK2

92 nM (IC₅₀)

体外実験

Pantothenate kinase-IN-2 (Compound 7) potently inhibits purified PanK1β, PanK2, and PanK3 isoforms with IC₅₀ values of 70 nM, 92 nM, and 25 nM, respectively^[1].
Pantothenate kinase-IN-2 binds specifically to the ATP-PanK3 complex, with an apparent binding constant of 0.3 μM^[1].
Pantothenate kinase-IN-2 (0.5-8 μM; 24 h) inhibits de novo CoA biosynthesis in cultured C3A cells with an apparent IC₅₀ of 0.9 μM, without reducing cell viability^[1].
Pantothenate kinase-IN-2 inhibits PanK3 and PanK1β in a luciferase-based enzyme assay with IC₅₀ values of 0.36 μM and 0.14 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

391.49

分子式

C₂₁H₂₁N₅OS

CAS 番号

902614-04-4

Appearance

Solid

Color

Light yellow to brown

SMILES

O=C(NC1=CC=CC(SC)=C1)CCC2=C(C)N3C(N=C2C)=C(C=CC=N4)C4=N3

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 12.5 mg/mL (31.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5543 mL	12.7717 mL	25.5434 mL
5 mM	0.5109 mL	2.5543 mL	5.1087 mL
10 mM	0.2554 mL	1.2772 mL	2.5543 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.25 mg/mL (3.19 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

純度とドキュメンテーション

純度: 98.18%

Select Batch:

データシート (273 KB) SDS (393 KB)

COA (248 KB) HNMR (167 KB) LCMS (133 KB) Elemental Analysis Report (106 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Sharma LK, et al. A high-throughput screen reveals new small-molecule activators and inhibitors of pantothenate kinases. J Med Chem. 2015;58(3):1563-1568. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5543 mL	12.7717 mL	25.5434 mL	63.8586 mL
	5 mM	0.5109 mL	2.5543 mL	5.1087 mL	12.7717 mL
	10 mM	0.2554 mL	1.2772 mL	2.5543 mL	6.3859 mL
	15 mM	0.1703 mL	0.8514 mL	1.7029 mL	4.2572 mL
	20 mM	0.1277 mL	0.6386 mL	1.2772 mL	3.1929 mL
	25 mM	0.1022 mL	0.5109 mL	1.0217 mL	2.5543 mL
	30 mM	0.0851 mL	0.4257 mL	0.8514 mL	2.1286 mL