PD 4'-oxyacetic acid

製品番号: HY-W761299 純度: 99.69%: Data Sheet SDS COA 取扱説明書
FAQs
Technical Support

PD 4'-oxyacetic acid is a carboxylic acid-functionalized cereblon ligand that can be used for PROTAC Degrader development.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

PD 4'-oxyacetic acid 構造式

CAS 番号 : 2633633-12-0

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 49	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 49	在庫あり	Estimated Time of Arrival: December 31
Solid
10 mg	$45	在庫あり	Estimated Time of Arrival: December 31
25 mg	$85	在庫あり	Estimated Time of Arrival: December 31
50 mg	$135	在庫あり	Estimated Time of Arrival: December 31
100 mg	$215	在庫あり	Estimated Time of Arrival: December 31
250 mg	$360	在庫あり	Estimated Time of Arrival: December 31
500 mg		お問い合わせ
1 g		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

Ligands for E3 Ligase アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B KLHL41

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

PD 4'-oxyacetic acid is a carboxylic acid-functionalized cereblon ligand that can be used for PROTAC Degrader development^[1].

IC₅₀ & Target

Cereblon

分子量

264.24

分子式

C₁₂H₁₂N₂O₅

CAS 番号

2633633-12-0

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)COC1=CC=C(N(C(N2)=O)CCC2=O)C=C1

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 12.5 mg/mL (47.31 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7845 mL	18.9224 mL	37.8448 mL
5 mM	0.7569 mL	3.7845 mL	7.5690 mL
10 mM	0.3784 mL	1.8922 mL	3.7845 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 99.69%

Select Batch:

データシート (269 KB) SDS (393 KB)

COA (246 KB) HNMR (120 KB) RP-HPLC (160 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Jarusiewicz JA, et al. Phenyl Dihydrouracil: An Alternative Cereblon Binder for PROTAC Design. ACS Med Chem Lett. 2023;14(2):141-145. Published 2023 Jan 4. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.7845 mL	18.9224 mL	37.8448 mL	94.6120 mL
	5 mM	0.7569 mL	3.7845 mL	7.5690 mL	18.9224 mL
	10 mM	0.3784 mL	1.8922 mL	3.7845 mL	9.4612 mL
	15 mM	0.2523 mL	1.2615 mL	2.5230 mL	6.3075 mL
	20 mM	0.1892 mL	0.9461 mL	1.8922 mL	4.7306 mL
	25 mM	0.1514 mL	0.7569 mL	1.5138 mL	3.7845 mL
	30 mM	0.1261 mL	0.6307 mL	1.2615 mL	3.1537 mL
	40 mM	0.0946 mL	0.4731 mL	0.9461 mL	2.3653 mL