2. Others Anti-infection
  3. Amino Acid Derivatives Bacterial
  4. Pentaglycine

Pentaglycine  (Synonyms: Tetraglycylglycine; Gly-Gly-Gly-Gly-Gly; NSC 96353)

Cat. No.: HY-W141916 Pureza: 99.47%
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Pentaglycine (Tetraglycylglycine; NSC 96353) is a bridging structure composed of five glycine residues. Pentaglycine serves as a characteristic peptidoglycan cross-bridge component of staphylococci and a specific substrate for lysostaphin. Pentaglycine maintains the integrity of the peptidoglycan cell wall of Staphylococcus aureus via peptide chain cross-linking and regulates bacterial growth. Pentaglycine expression is downregulated in high-glucose environments, inhibiting bacterial proliferation. Pentaglycine can be applied to studies related to Staphylococcus aureus infection.

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Pentaglycine

Pentaglycine Estructura química

No. CAS : 7093-67-6

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Pentaglycine Related Antibodies

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Descripciòn

Pentaglycine (Tetraglycylglycine; NSC 96353) is a bridging structure composed of five glycine residues. Pentaglycine serves as a characteristic peptidoglycan cross-bridge component of staphylococci and a specific substrate for lysostaphin. Pentaglycine maintains the integrity of the peptidoglycan cell wall of Staphylococcus aureus via peptide chain cross-linking and regulates bacterial growth. Pentaglycine expression is downregulated in high-glucose environments, inhibiting bacterial proliferation. Pentaglycine can be applied to studies related to Staphylococcus aureus infection[1][2].

In Vitro

Pentaglycine (25 mM glucose; 24 h) is indicated to have reduced expression in Staphylococcus aureus Newman cells cultured in LB medium with 25 mM glucose, which exhibit significantly increased resistance to lysostaphin lysis[1].
Pentaglycine (15 mM glucose; 6 h) has decreased bridge synthesis in Staphylococcus aureus Newman cells cultured in LB medium with 15 mM glucose, as mRNA expression of femA, femB, and femX is significantly reduced[1].
Pentaglycine (25 mM glucose; 24 h) is indicated to have reduced expression in Staphylococcus epidermidis RP62A and Staphylococcus haemolyticus SH01 cells cultured in LB medium with 25 mM glucose, which exhibit significantly increased resistance to lysostaphin lysis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pentaglycine Related Antibodies

Real Time qPCR[1]

Cell Line: Staphylococcus aureus Newman
Concentration: 15 mM glucose
Incubation Time: 6 h
Result: Significantly decreased relative mRNA expression of femA, femB, and femX compared to cells cultured without glucose.
Peso molecular

303.27

Fòrmula

C10H17N5O6
No. CAS
Appearance

Solid

Color

White to off-white

Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvente y solubilidad
In Vitro: 

H2O : 5 mg/mL (16.49 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2974 mL 16.4870 mL 32.9739 mL
5 mM 0.6595 mL 3.2974 mL 6.5948 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
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Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.2974 mL 16.4870 mL 32.9739 mL 82.4348 mL
5 mM 0.6595 mL 3.2974 mL 6.5948 mL 16.4870 mL
10 mM 0.3297 mL 1.6487 mL 3.2974 mL 8.2435 mL
15 mM 0.2198 mL 1.0991 mL 2.1983 mL 5.4957 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Pentaglycine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pentaglycine7093-67-6Tetraglycylglycine Gly-Gly-Gly-Gly-Gly NSC 96353NSC96353NSC 96353NSC-96353Amino Acid DerivativesBacterialfemBcell walllysostaphinStaphylococcus aureusStaphylococcus aureus Newman cellsStaphylococcus epidermidis RP62AStaphylococcus haemolyticus SH01 cellsfemXfemApeptidoglycanInhibitorinhibitorinhibit

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Pentaglycine
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