7093-67-6
Chemical Structure
Pentaglycine
Synonym(s): Tetraglycylglycine; Gly-Gly-Gly-Gly-Gly; NSC 96353
- CAS No.: 7093-67-6
- Formula:C10H17N5O6
- Molecular Weight:303.27
IUPAC Name: glycylglycylglycylglycylglycine
InChIKey: MXHCPCSDRGLRER-UHFFFAOYSA-N
SMILES: O=C(O)CNC(CNC(CNC(CNC(CN)=O)=O)=O)=O
Biological Activity: Pentaglycine (Tetraglycylglycine; NSC 96353) is a bridging structure composed of five glycine residues. Pentaglycine serves as a characteristic peptidoglycan cross-bridge component of staphylococci and a specific substrate for lysostaphin. Pentaglycine maintains the integrity of the peptidoglycan cell wall of Staphylococcus aureus via peptide chain cross-linking and regulates bacterial growth. Pentaglycine expression is downregulated in high-glucose environments, inhibiting bacterial proliferation. Pentaglycine can be applied to studies related to Staphylococcus aureus infection[1][2].
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Pentaglycine | 99.47% | Pentaglycine (Tetraglycylglycine; NSC 96353) is a bridging structure composed of five glycine residues. Pentaglycine serves as a characteristic peptidoglycan cross-bridge component of staphylococci and a specific substrate for lysostaphin. Pentaglycine maintains the integrity of the peptidoglycan cell wall of Staphylococcus aureus via peptide chain cross-linking and regulates bacterial growth. Pentaglycine expression is downregulated in high-glucose environments, inhibiting bacterial proliferation. Pentaglycine can be applied to studies related to Staphylococcus aureus infection. | ||||||||||||||||||||
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References
- [1]. Luo Z, et al. Reduced growth of Staphylococcus aureus under high glucose conditions is associated with decreased pentaglycine expression[J]. Frontiers in Microbiology, 2020, 11: 537290.
- [2]. Monteiro JM, et al. The pentaglycine bridges of Staphylococcus aureus peptidoglycan are essential for cell integrity. Sci Rep. 2019;9(1):5010. Published 2019 Mar 21. [Content Brief]
