2. Others Anti-infection
  3. Amino Acid Derivatives Bacterial
  4. Pentaglycine

Pentaglycine  (Synonyms: Tetraglycylglycine; Gly-Gly-Gly-Gly-Gly; NSC 96353)

Cat. No.: HY-W141916 Purity: 99.47%
COA
SDS
Handling Instructions Technical Support

Pentaglycine (Tetraglycylglycine; NSC 96353) is a bridging structure composed of five glycine residues. Pentaglycine serves as a characteristic peptidoglycan cross-bridge component of staphylococci and a specific substrate for lysostaphin. Pentaglycine maintains the integrity of the peptidoglycan cell wall of Staphylococcus aureus via peptide chain cross-linking and regulates bacterial growth. Pentaglycine expression is downregulated in high-glucose environments, inhibiting bacterial proliferation. Pentaglycine can be applied to studies related to Staphylococcus aureus infection.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Pentaglycine

Pentaglycine Chemical Structure

CAS No. : 7093-67-6

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Based on 1 publication(s) in Google Scholar

Pentaglycine Related Antibodies

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Description

Pentaglycine (Tetraglycylglycine; NSC 96353) is a bridging structure composed of five glycine residues. Pentaglycine serves as a characteristic peptidoglycan cross-bridge component of staphylococci and a specific substrate for lysostaphin. Pentaglycine maintains the integrity of the peptidoglycan cell wall of Staphylococcus aureus via peptide chain cross-linking and regulates bacterial growth. Pentaglycine expression is downregulated in high-glucose environments, inhibiting bacterial proliferation. Pentaglycine can be applied to studies related to Staphylococcus aureus infection[1][2].

In Vitro

Pentaglycine (25 mM glucose; 24 h) is indicated to have reduced expression in Staphylococcus aureus Newman cells cultured in LB medium with 25 mM glucose, which exhibit significantly increased resistance to lysostaphin lysis[1].
Pentaglycine (15 mM glucose; 6 h) has decreased bridge synthesis in Staphylococcus aureus Newman cells cultured in LB medium with 15 mM glucose, as mRNA expression of femA, femB, and femX is significantly reduced[1].
Pentaglycine (25 mM glucose; 24 h) is indicated to have reduced expression in Staphylococcus epidermidis RP62A and Staphylococcus haemolyticus SH01 cells cultured in LB medium with 25 mM glucose, which exhibit significantly increased resistance to lysostaphin lysis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pentaglycine Related Antibodies

Real Time qPCR[1]

Cell Line: Staphylococcus aureus Newman
Concentration: 15 mM glucose
Incubation Time: 6 h
Result: Significantly decreased relative mRNA expression of femA, femB, and femX compared to cells cultured without glucose.
Molecular Weight

303.27

Formula

C10H17N5O6
CAS No.
Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 5 mg/mL (16.49 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2974 mL 16.4870 mL 32.9739 mL
5 mM 0.6595 mL 3.2974 mL 6.5948 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.47%

SDS (393 KB)

COA (242 KB) RP-HPLC (86 KB) MS (255 KB) Elemental Analysis Report (101 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.2974 mL 16.4870 mL 32.9739 mL 82.4348 mL
5 mM 0.6595 mL 3.2974 mL 6.5948 mL 16.4870 mL
10 mM 0.3297 mL 1.6487 mL 3.2974 mL 8.2435 mL
15 mM 0.2198 mL 1.0991 mL 2.1983 mL 5.4957 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Pentaglycine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pentaglycine7093-67-6Tetraglycylglycine Gly-Gly-Gly-Gly-Gly NSC 96353NSC96353NSC 96353NSC-96353Amino Acid DerivativesBacterialfemBcell walllysostaphinStaphylococcus aureusStaphylococcus aureus Newman cellsStaphylococcus epidermidis RP62AStaphylococcus haemolyticus SH01 cellsfemXfemApeptidoglycanInhibitorinhibitorinhibit

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