Pentosan Polysulfate Sodium (W/W 43%)

Name: Pentosan Polysulfate Sodium (W/W 43%)
Brand: MedChemExpress
SKU: HY-A0203A
Rating: 5.0 (2 reviews)

Cat. No.: HY-A0203A Purity: 43%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Pentosan Polysulfate Sodium is an orally bioavailable, semi-synthetic medication with anti-inflammatory and pro-chondrogenic properties. Pentosan Polysulfate Sodium also is a potent and selective anti-HIV agent. Pentosan Polysulfate Sodium is used for the treatment of interstitial cystitis.

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Pentosan Polysulfate Sodium (W/W 43%) 화학구조

CAS No. : 140207-93-8

사이즈	재고	수량
무료 샘플 (0.1 - 0.2 mg)	지금 신청하기
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 2 publication(s) in Google Scholar

Other Forms of Pentosan Polysulfate Sodium (W/W 43%):

Pentosan Polysulfate 견적 받기

2 Publications Citing Use of MCE Pentosan Polysulfate Sodium (W/W 43%)

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HIV HIV-1 HIV-2

Biological Activity
순도&문서
References
고객리뷰

제품 설명

IC₅₀ & Target^[2]

HIV-1

In Vitro

Pentosan Polysulfate Sodium has been shown to inhibit HIV-1 activity with an ED₅₀ of 0.19 μg/mL in MT-4 cells. It inhibits HIV-1 antigen expression in HUT-78 cells at an ED₅₀ of 0.02 μg/mL, and complete inhibition of HIV-1 antigen expression is obtained at a concentration of 4.0 μg/mL^[2].
Pentosan Polysulfate Sodium suppresses NF-κB, decreases the proinflammatory actions of TNFα, and decreases high glucose and advanced glycation end products (AGEs) stimulated MCP-1 production^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Pentosan Polysulfate Sodium has been shown to decreases interstitial inflammation and glomerulosclerosis in 5/6 nephrectomized rats. Pentosan polysulfate treatment preserves renal function, significantly reduces albuminuria, and markedly decreases the severity of renal lesions, including tubulointerstitial inflammation. Pentosan Polysulfate Sodium also reduces upregulation of TNFα and proinflammatory genes in aging diabetic kidneys^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

4000-6000

CAS No.

140207-93-8

Appearance

Solid

Color

White to off-white

SMILES

[Pentosan Polysulfate (Sodium) (W/W 43%)]

선적

Room temperature in continental US; may vary elsewhere.

보관

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

순도&문서

Purity: 43%

Select Batch:

Data Sheet (269 KB) SDS (251 KB)

COA (231 KB)

Handling Instructions (2659 KB)

References

[1]. Schuchman EH, et al. Pentosan polysulfate: a novel therapy for the mucopolysaccharidoses. PLoS One. 2013;8(1):e54459. [Content Brief]

[2]. Baba M, et al. Pentosan polysulfate, a sulfated oligosaccharide, is a potent and selective anti-HIV agent in vitro. Antiviral Res. 1988 Sep;9(6):335-43. [Content Brief]

[3]. Wu J, et al. Inhibition of inflammation by pentosan polysulfate impedes the development and progression of severe diabetic nephropathy in aging C57B6 mice. Lab Invest. 2011 Oct;91(10):1459-71. [Content Brief]